In this paper, we studied a single-product supply chain consisting of one supplier and one retailer, defined the relevant parameters of the supply chain, then established the product marketing optimization model with the revenue of the supplier, the retailer and the supply chain as a whole as the objective function, on the basis of which we designed a solution for the optimization of the product marketing of the supply chain and presented the constraining conditions to be satisfied, and at the end, built a marketing orientation mechanism to optimize the product marketing of the supply chain dominated by the retailer.