对中药微粉粒度常用的测定方法进行简单阐述,分析各种方法存在的优缺点,并重点介绍激光衍射法.采用Mastersizer 3000激光粒度仪对板青超微粉、黄芪超微粉和四味穿心莲散超微粉的粒度大小及其分布进行测定,指出干法激光衍射法较其他方法更适合用于三者粒度的测定.

The common determination methods of partical size of traditional Chinese medicinal micropowder were expounded briefly. The advantages and disadvantages of every testing methods were analyzed ,and laser diffraction method was narrated in detail. The particle sizes and particle size distributions of Banqing micropowder ,Huangqi-micropowder and Siweichuanxinliansan micropowders were tested by Mastersizer 3000 laser particle analyzer. Dry laser diffraction method is thought to be the most suitable to particle size testing of Chinese medicinal micropowders.

目的：建立激光散射法测定磺胺嘧啶银原料粒度分布。方法：采用Malvern Mastersizer 2000激光粒度分析仪；Hydro 2000 MU湿法进样器；泵速：2000 rpm ，样品折射率：1.679，颗粒吸收率：0.01，分散介质折射率：1.33，测量次数：5次；样品与背景测量时间：10 s，遮光度：10%～20%。结果：7批原料d（0.5）均小于10μm，RSD均小于6%，d（0.1）和d（0.9）均小于3.5μm和25μm， RSD均小于10%，符合《中国药典》相关要求。结论：所建立方法经考察，可用于磺胺嘧啶银原料的粒度测定。

Objective: To establish a laser light scattering method for the determination of particle size distribution for sulfadiazine silver. Methods:The Malvern Mastersizer 2000 laser size analyzer and the Hydro 2000 MU wet autosampler were used. The conditions of determination were as follows: the pump speed of 2000 rpm,the sample RI of 1.679, the sample absorption of 0.01,the measurement times of 5 times, the measurement time of background and sample of 10 s,and the obscuration of 10%-20%. Results:RSD of d(0.5) was lower than 6%,and that of d(0.1) and d(0.9) was lower than 10%. All the d(0.1) of 7 batches of sulfadiazine silver was less than 3.5μm, the d(0.5) was less than 10μm and the d(0.9) was less than 25μm which were all in line with the requirements of China Pharmacopeia. Conclusion:The method was simple, accurate and producible,which was suitable for the particle size control of sulfadiazine silver.

通过HLG-30型纳米化粉碎机批量制备纳米Al2O3,使用纳米激光粒度仪分析其粒度及粒度分布,并用扫描电子显微镜(SEM)和透射电子显微镜(TEM)观察其大小和形貌,采用X射线衍射(XRD)表征其晶型结构,通过电感耦合等离子体发射光谱(ICP-AES)检测杂质元素的含量,研究其纯度。结果表明,制备所得的Al2O3粒度分布窄,大部分颗粒的粒径40nm,为α型晶体,并且纯度99.99%,具有广阔的应用前景。

Nano Al2 O3 was obtained in batch by using nano pulverized machine HLG-30.Size and size distribution of the nano Al2 O3 were traced by the nano laser size analyzer,at the same time,the size and morphology of the particles were characterized by using SEM and TEM.The structure of nano Al2 O3 was detected by XRD,The ICP-AES was employed to test the contents of impurity element and the purity quotient was researched.The results showed that the pulverized nano Al2 O3 got a narrow particle size distribution and the size of most of the particles was under 40 nm,which was characterized in alpha crystal form.The product caught a high purity surpassing 99.99% and there would be a good application.

以丙烯酰胺（AM）、丙烯酸（AA）、2-丙烯酰胺-2-甲基丙磺酸（AMPS）为单体,Span-80和Tween-80作为复合乳化剂,用过硫酸铵为引发剂,通过反相乳液聚合法制备了交联P（AM-AAAMPS）微球。分别采用红外光谱仪进行结构表征,扫描电镜观察微球形貌,激光粒度分析仪分析微球粒度,光学显微镜观察微球在水中的分散性。

Cross-linking copolymer microspheres of P(AM-AA-AMPS) was prepared by in-verse emulsion with acrylamide (AM) ,acrylic acid (AA) ,2-acrylamide-2-methyl propane sulfo-nic acid (AMPS) as the monomers ,Span-80 and Tween-80 as compound emulsifiers ,ammonium persulfate as initiator .The structure of the microspheres was characterized by infrared spectros-copy ,the morphology was studied by scanning electron microscope ,particle size of microspheres was analyzed by laser particle size analyzer ,and dispersibility in water of the microspheres was observed by optical microscopy .

为了研究灌河口海区的沉积环境,利用激光粒度仪对位于灌河口的柱状样 GH-1孔进行了沉积物粒度分析,根据粒级-标准偏差方法对此柱状样的环境敏感粒级进行了计算,并结合对粒度概率曲线图的分析来对该区域进行沉积环境的研究,从而探讨了该环境敏感粒度组分的环境指示意义。在研究区内确定环境敏感粒度组分为250~32μm,32~16μm,代表沉积过程中的两种动力机制,分别是风暴流和沿岸流。通过该柱状样的210Pb测年可以得到沉积速率和沉积环境的变化,上段沉积速率较大为1.9 cm/a,下段20 cm沉积速率较低为0.4 cm/a。

In order to explore the deposition environment of the Guanhe Estuary, grain-size analysis of sediment GH-1 drilling, retrieved from Guanhe Estuary, was carried out by using a Malvern 2000 grain-size analyzer. The environmentally sensitive grain size components were calculated according to variations in the grain-size standard deviation. The deposition environment was studied combined with the analysis of grain size probability curve. At the same time, the environmental implications were discussed. Two environmentally sensitive grain-size compo-nents, 250~32 μm and 32~16 μm, were identified, representing two dynamic mechanisms in the process of sedi-mentary, storm flow and coastal current. The variation of deposition rate and sedimentary environment can be ob-tained by using the 210Pb technique. The results show that the deposition rate was larger at 1.9 cm/a, and the deposi-tion rate of the last 20 cm was smaller at 0.4 cm/a.