In this study, bleeding sap of sponge gourd uses as main raw material, rose, sugar, glucose, starch used as auxiliary material, a natural lozenge, which has whitening function, is developed. By single-factor experiments and an orthogonal experiment of four factors and three levels, the formula of the main and auxiliary material is determined in terms of sensory indexes. The results are bleeding sap of sponge 20%, rose 3%, starch 20%, dextrin 9%, milk powder 20%, sugar 15%, glucose 7%, citric acid 1.1% and magnesium stearate 1%. The key technology condition is optimized in an orthogonal experiment of three factors and three levels in terms of sensory indexes. The results are that the material is dried at 60 ℃ for 3 h, after addition of 6%apple juice.