目的 评价注射用丹参多酚酸盐的安全性.方法 利用中国期刊全文数据库、万方数字化期刊全文库等文献数据库进行检索,以“丹参多酚酸盐”为检索词,检索注射用丹参多酚酸盐配伍安全性的文献,归类并分析,以配伍液有无颜色变化、气泡、混浊或沉淀产生为观察指标.结果 共检出相关论文34篇,剔除重复报道,共查阅有效文献31篇,共计有18种药物与注射用丹参多酚酸盐存在配伍禁忌,多为丹参多酚酸盐40 ~ 200 mg溶解于100~250 ml的0.9%氯化钠注射液或5%葡萄糖注射液中,其中浓度最高为2.0 g/L,大多为0.8 g/L.主要表现为连续输注时输液管及墨菲管中液体立即出现变色或混浊,发生在两药配伍加药时l例,发生在输液过程中从墨菲管直接推注时2例,发生在配伍实验时7例,发生在更换输液或连续输注时24例.与注射用丹参多酚酸盐有配伍禁忌的药物中,抗菌药物6类,8个品种,包括喹诺酮类3种(左氧氟沙星、环丙沙星、莫西沙星)、抗真菌药1种(卡泊芬净)、四环素类1种(替加环素)、青霉素类1种(阿莫西林钠氟氯西林钠)、头孢菌素类1种(头孢美唑钠)、氨基糖苷类1种(依替米星).注射用丹参多酚酸盐与抗菌药物类发生配伍禁忌共17例,喹诺酮类报道反应最多,有12例,其中左氧氟沙星有8例.注射用丹参多酚酸盐与非
Objective To monitor the safety of savianolate Injections.Methods The literatures of the safety of savianolate Injections were searched from China National Knowledge Infrastructure and WANFANG Med Online with " savianolate" as the keyword.Results Thirty four literatures were included and 18 medicines were reported incompatible with salvianolate.40-200 mg of salvianolate was dissolved in 100-250 ml of 0.9% sodium chloride solution or 5% glucose solution.The concentration was 0.8 g/L with the highest of 2.0 g/L.The common phenomenon of incompatibility was color change or turbidity in the infusion tube and the Murphy''s tube.1 case of incompatibility occurred when two drugs were mixed.Regarding the drugs which were incompatible with salvianolate,there were 6 different types of antibacterial drugs,including 3 quinolones (levofloxacin,ciprofloxacin,moxifloxacin),1 antifungal drug (caspofungin),1 tetracycline (tigecycline),1 penicillins (amoxicillin flucloxacillin sodium),1 cepha