探讨血清CA15-3、CA50、CA19-9和IL-8检测对乳腺癌患者诊断的临床意义。方法:应用放射免疫法和化学发光法对34例乳腺癌患者(均为女性)进行血清的CA15-3、CA50、CA19-9和IL-8检测,并与34名正常人(均为女性)进行相关对比分析。结果:乳腺癌患者的CA15-3、CA50和IL-8含量水平明显高于对照组(P0.05),而CA19-9与正常人对照组无明显差异(P0.05)。结论:血清CA15-3、CA50和IL-8的检测对乳腺癌的发病、预防、诊断和治疗均有重要的临床价值。

Objective:To investigate the clinical signficance of differences on serum CA15-3,CA50,CA19-9,IL-8 levels detection in patients with breast cancer. Methods:Serum CA15-3,CA50,CA19-9,IL-8 concentration from 34 patients (female) with breast cancer and 34 healthy normal controls (female) were determined by RIA and CLIA. Results:The serum CA15-3,CA50,IL-8 levels in patients with breast cancer were significant higher than those in controls. But the serum CA19-9 levels were no significant difference from those in controls.Conclusion:Detection of serum CA15-3,CA50,IL-8 levels might be of prognostic importance in patients with breast cancer.

目的比较联合检测胃癌患者血清癌胚抗原(CEA)、糖类抗原(CA19-9、CA50、CA72-4)的临床意义。方法分别检测38例胃癌患者(胃癌组)、34例胃炎患者(胃炎组)、37例胃溃疡患者(胃溃疡组)及36例健康者(对照组)血清中CEA、CA19-9、CA50、CA72-4水平。结果 4项标志物检测的灵敏度分别为49.7%(CEA)、54.1%(CA19-9)、38.2%(CA50)、41.7%(CA72-4),联合检测CEA、CA19-9、CA50、CA72-4灵敏度为79.6%。结论联合检侧CEA、CA19-9、CA50、CA72-4对胃癌的诊断及疗效观察具有重要临床价值。

Objective To compare the clinical significance of combined detection of serum carcino-embryonic antigen (CEA),carbohydrate antigens (CA19-9,CA50 and CA72-4)in the di-agnosis of patients with gastric cancer.Methods The levels of serum CEA,CA19-9,CA50 and CA72-4 in patients with gastric cancer (gastric group,n =38),gastritis (gastritis group,n =34) and gastric ulcer (gastric ulcer group,n =37)as well as healthy people (control group,n =36) were detected respectively.Results The levels of sensitivity of CEA,CA19-9,CA50 and CA72-4 were 49.7%,54.1%,38.2% and 41.7% respectively,while the level of sensitivity of combined detection was 79.6%.Conclusion Combined detection of CEA,CA19-9,CA50 and CA72-4 shows a great clinical significance in the diagnosis and efficacy observation of patients with gastric cancer.

目的：探讨血清 ca50、ca125、ca153、afP 和 cea 对卵巢癌的诊断价值。方法采用化学发光免疫方法对57例卵巢癌、55例卵巢良性肿瘤及50例健康体检者血清进行定量测定。结果卵巢癌组血清 ca125、ca50、ca153、afP 和 cea 水平明显高于正常对照组笔卵巢良性肿瘤组；正常对照组、卵巢良性肿瘤组和卵巢癌组联合检测五种肿瘤标志物的阳性率分别为2.00%、18.18%、96.49%。结论联合检测血清 ca125、ca50、ca153、afP 和 cea 对卵巢癌的诊断具有重要意义。

Objective to study the role of combination detection of carbohydrate antigen in the diagnosis of ovarian cancer.Methods in 57 cases with ovarian cancer, 55 patients with benign ovarian tumor and 50 normal subjects, the levels of serum ca50, ca125, ca153,afP and cea) were determined use chemiluminescence method Results the levels of serum ca50, ca125, ca153, afP and cea were significantly higher than the patients with benign ovarian tumor and normal subjects. the positive rate of tumor markers in patients with ovarian cancer, patients with benign ovarian tumor and normal subjects were 2.00%, 18.18%, and 96.49%. Conclusions combination detection of serum ca50, ca125, ca153, afP and cea has important implications for the diagnosis of ovarian cancer.

目的探讨血清癌胚抗原(CEA)、癌抗原19-9(CA19-9)、癌抗原125(CA125)、癌抗原724(CA724)、癌抗原50(CA50)对胰腺癌的临床诊断价值。方法用雅培ARCHITECT i2000型化学发光仪检测18例胰腺癌患者、20例胰腺术后患者、15例胰腺炎患者及14例健康体检者血清CEA、CA19-9、CA125、CA724、CA50的含量,胰腺癌组分别与良性病变组和正常对照组比较。结果胰腺癌组中CA19-9、CA125、CEA血清水平较胰腺良性疾病组和健康查体组明显升高,其中以血清CA19-9水平升高最显著。与健康人相比,胰腺良性病组CA19-9、CEA、Ca724升高,差异有统计学意义(P0.05)。而各组CA724未出现统计学差异。CA19-9诊断胰腺癌灵敏度为77.8%,特异度为83.7%,准确率为79.1%。CA19-9+CA125联合检测灵敏度和特异度最高,分别为100%和79.6%,准确率为85.1%。结论血清CA19-9、CEA、CA125在胰腺癌的诊断中有一定的临床应用价值,联合应用可提高胰腺癌的诊断率。

Objective To explore the clinical diagnostic significance of serum CA19 - 9,CEA,CA125,CA724 and CA50 in patients with malignant tumors of digestive system. Methods Serum levels of CA19 - 9,CEA,CA125,CA724 and CA50 were detected by Abbott AR-CHITECT i2000 from 18 patients with pancreatic cancer,35 patients with pancreatic benign diseases(20 patients with post - pancreatic operation and 15 patients with acute pancreatitis)and 14 healthy controls. Results Serum levels of CA19 - 9,CA125 and CEA were significantly higher in pancreatic cancer group than those of benign pancreatic disease group,while serum level of CA19 - 9 was the highest(646. 33 ± 124. 15 ug/ ml). In comparison with healthy controls,serum levels of CA19 - 9,CEA and CA724 were increased in patients with benign pancreatic diseases,and the difference was statistically significant( P ﹤ 0. 05). There was no difference in serum level of CA724 among these three groups. The sensitivity of CA19 - 9 was 77. 8% ,its specif

目的探讨血清癌胚抗原(CEA)、糖类抗原50(CA50)、细胞角质蛋白(CYFRA21-1)、鳞状细胞癌抗原(SCC)和神经烯醇化酶(NSE)对晚期肺癌化疗疗效及进展评估的意义。方法分别采取2008~2012年确诊的肺癌(Ⅲb~Ⅳ期)患者的化疗前、缓解及进展时的血清标本,检测每份血清标本CEA、CA50、CYFRA21-1、SCC和NSE 5种肿瘤标记物,比较它们之间的差异及探讨其与不同病理类型的晚期肺癌化疗疗效的关系。结果综合考虑疗效与病理类型两方面影响因素,CEA、CA50、CYFRA21-1、SCC和NSE的数值变化差异均有统计学意义(PCEA=0.034、PCA50=0.003、PCYFRA21-1=0.039、PSCC=0.019和PNSE=0.000),且CEA及CA50数值变化在肺腺癌组最为明显,CYFRA21-1及SCC数值变化在肺鳞癌组最为明显,NSE数值变化在肺小细胞癌组最为明显。结论肿瘤标志物CEA、CA50、CYFRA21-1、SCC和NSE可分别作为晚期肺腺癌、鳞癌及小细胞癌的化疗疗效及进展评估的重要指标。

Objective To investigate the significance of cancer embryonic antigen (CEA) ,carbohydrate antigen 50(CA50) ,cytokaratin(CYFRA21-1) ,squamous cell cancer antigen(SCC) and neuron specific enolase(NSE) on the chemotherapy efficacy and the progress evaluation in advanced lung cancer .Methods The serum samples were col-lected before chemotherapy ,in remission and progression from the patients diagnosed with advanced lung cancer (IIIb-IV) during 2008-2012 .Each sample was detected the five tumor markers CEA ,CA50 ,CYFRA21-1 ,SCC and NSE . The differences among them were compared and their relationship with chemotherapy efficacy in different pathologi -cal types of advanced lung cancer was investigated .Results Considering the influencing factors of efficacy and patho-logical types ,the differences of CEA ,CA50 ,CYFRA21-1 ,SCC and NSE values had statistical significance (PCEA =0 .034 ,PCA50 = 0 .003 ,PCYFRA21-1 = 0 .039 ,PSCC = 0 .019 and PNSE = 0 .000) .The changes of CEA and CA50 values wer