目的比较中段食管癌手术治疗术式的利弊,以提高食管癌的手术疗效。方法选择2010年1月至2012年6月位于食管中段的食管癌住院手术患者110例,依据术式不同,即经右胸Ivor-Lewis手术和左胸Sweet手术,将病例分为Ivor-Lewis组55例和Sweet组55例。对比分析2组术后切除标本的食管长度、肿瘤浸润和切除距离、切缘癌残留的发生率、胸腔和腹腔淋巴结清除的数量及癌浸润淋巴结的阳性率等,并以问卷调查的方式对医师参加Ivor-Lewis组和Sweet组术中处理胸部和腹部的解剖学问题进行评分比较。结果在食管切除长度、淋巴结清除个数方面Ivor-Lewis组明显大于Sweet组(P0.01);Ivor-Lewis组食管癌切缘癌残留阳性发生率为1.82%,显著低于Sweet组的21.82%(P0.01);问卷调查手术医师对2组术中解剖问题评分Ivor-Lewis组明显优于Sweet组。结论食管中上段癌外科手术建议采取Ivor-Lewis术式,贲门部及下段食管癌适宜Sweet手术。

Objective In order to improve the surgical treatment for midpiece esophageal carcinoma, different surgical ways were com-pared. Methods From January 2010 to June 2012, 110 patients with midpiece esophageal cancer in our hospital were divided into the Ivor-Lewis group (55 cases) and the Sweet group (55 cases) according to different surgical ways, that is to say Ivor-Lewis surgery via right chest and Sweet surgery through left chest. Length of specimens, rang of tumor invasion, distance of removal, incidence of residual carcinoma in the esophageal edges, number of lymph nodes removed in chest and abdomen, and positive rate of carcinoma infiltrated lymph nodes were compared between the two groups. Questions of surgical anatomy were investigated through questionnaire among surgeons of the two groups, and the scores of both groups were analysed. Results The length of resected specimens and number of lymph nodes removed in Ivor-Lewis group was significantly lager than that of the Sweet group

根据GenBank 中公布的甘薯羽状斑驳病毒（Sweet potato feathery mottle virus,SPFMV） 外壳蛋白（犆犘）基因和甘薯褪绿矮化病毒（Sweet potato chlorotic stunt virus,SPCSV）热激蛋白（犎狊狆70）基因序列保守区域设计了2对特异性引物,通过RT-PCR 反应程序的优化,建立了能同时检测SPFMV 和SPCSV 的双重PCR检测体系.该检测体系能够1次扩增出SPFMV 和SPCSV 的特异性片段,片段大小为461bp和304bp,测序结果表明,2种病毒序列与参考序列的同源性达93%以上.

A duplex PCR protocol for the detection of two main viruses in sweet potato was developed based on the coat protein (CP )gene of Sweet potato feathery mottle virus (SPFMV)and the (Hsp70)gene of Sweet potato chlorotic stunt virus (SPCSV).They were able to amplify unique DNA fragments of 461 bp and 304bp in a single PCR reaction.The sequence analysis suggst that the two viruses shared at least 93 percent homology with other related viruses.

目的回顾性分析改良Ivor-Lewis手术或Sweet手术后辅助放化疗治疗胸段食管鳞癌的疗效及影响预后的危险因素。方法 914例胸段食管鳞癌患者按不同术式分为改良Ivor-Lewis手术组（n=424例）和Sweet手术组（n=490）;其中Ⅱ期及以上患者按术后有无联合放化疗分为单纯手术组（n=297）与术后辅助放化疗组（n=446）。采用Kaplan-Meier法计算总生存（OS）,Log-rank检验比较不同手术方式及术后是否联合放化疗患者的生存差异,Cox比例风险模型分析影响预后的危险因素。结果改良Ivor-Lewis术组与Sweet术组患者的1、3、5年生存率分别为86.3%、63.7%、44.5%和90.2%、64.9%、45.0%。单纯手术组与术后辅助放化疗组的中位OS分别为36.1个月和46.1个月（P=0.004）。改良Ivor-Lewis术组单纯手术者和术后辅助放化疗者的中位OS分别为34.6个月和46.8个月,差异有统计学意义（P=0.038）。Sweet术组单纯手术者和术后辅助放化疗者的中位OS分别为37.0个月和45.1个月,差异有统计学意义（P=0.036）。2种术式无论是单纯手术亚组之间或术后联合放化疗亚组之间的中位OS比较,差异均无统计学意义（P〉0.05）。改良Ivor-Lewis术Ⅱ期患者术后接受放化疗的中位OS较单纯手术者并未明显获益（P〉0.05）,在Sweet术

Objective To retrospectively investigate the efficacy of modified Ivor?Lewis esophagectomy or Sweet esophagecto?my plus postoperative chemoradiotherapy in the treatment of thoracic esophageal squamous cell carcinoma and analyze the risk factors affecting the prognosis. Methods Ninety hundred and fourteen patients with thoracic esophageal squamous cell carcinoma were divided into modified Ivor?Lewis esophagectomy group( n=424) or Sweet esophagectomy group( n=490) . For the patients with stageⅡ and a?bove, they were divided into single operation group( n=297) and postoperative chemoradiotherapy group( n=446) . The patients were followed up and the survival time was calculated by Kaplan?Meier method. Difference in survival time was compared by Log?rank test. Cox regression analysis was performed to identify risk prognostic factors. Results The 1?, 3?, 5?year survival rates of modified Ivor?Lewis esophagectomy group and Sweet esophagectomy group were 86?3%, 63?7%, 44?5% and 90?2

目的提高不明原因发热(fever of unknown origin,FUO)病因诊断中对慢性粒单核细胞白血病(chronic myelomonocytic leukemia,CMML)的认识,探讨CMML临床特点,Sweet综合征(Sweet''s syndrome,SS)与CMML的关系。方法回顾1例以不明原因发热就诊,合并SS,最后确诊为CMML青年男性患者的临床资料并复习相关文献。结果患者长期发热,病程中出现痛性皮疹,皮肤活检示中性粒细胞浸润符合SS。肺CT示肺部感染,巨细胞病毒COPY阳性,外周血单核细胞计数持续高于1.0×109/L,骨髓形态可见2系病态造血,先后诊断为SS合并肺炎,巨细胞病毒感染等,抗感染及激素治疗无效,并除外其他引起单核细胞计数高的疾病后诊断为CMML。结论 CMML临床症状可有长期发热,SS可为CMML前驱症状。

Objective To improve our understanding of chronic myelomonocytic leukemia (CMML) in etiological diagnosis of fever of unknown origin (FUO) and to study the clinical characteristics of CMML and the relation between Sweet''s syndrome (SS) and CMML. Methods Clinical data about 1 patient with FUO accompanying SS were retrospectively analyzed with its relevant literature reviewed.Results The patient suffered from chronic fever with painful skin rashes. Laboratory test showed that the number of peripheral mononuclear cells was>1.0×109/L and bone marrow morphology revealed pathological hematopoietic cells. The patient who was diagnosed with SS accompanying pneumonia and cytomegalovirus infection had no response to anti-infection and hormone therapy. After other causes that increased the number of mononuclear cells were excluded, the patient wasfinally diagnosed with CMML.Conclusion CMML is manifested as chronic fever with SS as its precursory symptom.

语言中的味觉词大多都可以用来表达多种意思。认知语言学认为，语言反映人的认知且需要通过人的认知获得解释。以“sweet／甜”和“bitter／苦”为例，从认知角度对味觉词语义拓展的分析表明，味觉词一词多义现象是概念隐喻、概念转喻两种认知方式抑或两种认知方式共同作用的产物。研究结果一方面有助于词语多义现象研究的纵深发展，同时对多义词的教学具有启示作用。

Most taste words in language are polysemous.Cognitive linguistics holds that language reflects hu-man cognition and needs to be explained by means of human cognition.The analysis of the semantic extension of the two taste words“sweet/Tian” and“bitter/Ku” indicated that polysemy of taste words is the product of conceptual metaphor,conceptual metonymy, or the joint function of conceptual metaphor and conceptual metonymy.The study features a move to in-depth investigation of polysemy on the one hand, and can shed light on teaching of polysemous words on the other.