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双语推荐：Sensorineural)

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The goal of cochlear implantation (CI) surgery is to make all patients with profound sensorineural hearing loss achieve satisfied postoperative performance.It will contribute to the excellent postoperative performance to insert the full length of the electrode array into the scala tympani with little trauma to the structure.
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目的探讨组蛋白去乙酰化酶2（histone deacetylase 2,HDAC2）水平与突发性聋（sudden sensorineural hearing loss,SSNHL）患者糖皮质激素（glucocorticoid,GC）抵抗的关系。方法选择难治性SSNHL患者20例,所有患耳鼓室内灌注甲强龙20mg/d,连续10天,同时辅以全身静脉滴注营养神经及改善微循环药物。对照组为10例正常听力志愿者。分离所有研究对象的外周血单个核细胞（peripheral blood mononuclear cell,PBMC）,提取细胞核蛋白以及总RNA,分别用HDAC2活性检测试剂盒以及real time PCR的方法,检测受试者PBMC中HDAC2的蛋白活性以及HDAC2mRNA的表达情况,并随访SSNHL患者听力,根据听力恢复情况将SSNHL患者分为GC有效组和GC无效组,探讨HDAC2水平与GC抵抗的关系。结果 20例SSNHL患者中,GC有效8例,GC无效12例,治疗前GC有效组及无效组患耳PTA分别为75.21±9.44和80.98±12.73dB HL,治疗后分别为40.83±14.37和77.92±12.25dB HL;治疗前突聋患者HDAC2蛋白活性OD值（GC有效组0.664±0.022,GC无效组0.659±0.043）显著低于对照组（0.726±0.024）,而HDAC2mRNA表达量（GC有效组0.079±0.023,GC无效组0.083±0.047）显著高于对照组（0.035±0.022）,治疗后,两组患者HDAC2mRNA表达量（
Objective To evaluate expression of HDAC2 in peripheral blood mononuclear cells(PBMCs)from glucocorticoid-resistant versus glucocorticoid-sensitive patients with sudden sensorineural hearing loss and identi-ty the relationship between the level of HDAC2 and glucocorticoid insensitivity.Methods PBMCs were collected from10 patients with deviation of nasal septum (control group)and 20 sudden sensorineural hearing loss patients be-fore and after intratympanic methylprednisolone for 10 days.We divided the SSNHL patients into 2 groups (GC sensitive group and GC insensitive group)according to their hearing recovery.Real time PCR and HDAC2 Assay Kit were used to detect the expression level of HDAC2 mRNA and HDAC2 activity in PBMCs.The data were analyzed with SPSS 17.0 software.ResuIts Before intratympanic methylprednisolone,the level of HDAC2 activity were sig-nificantly depressed in SSNHL patients,while the HDAC2 mRNA expressing much higher than the control group. The expression lev

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目的 探讨症状性先天性巨细胞病毒(cytomegalovirus,CMV)感染新生儿脑脊液(cerebrospinal fluid,CSF) CMV DNA载量与感音性听力损伤(sensorineural hearing loss,SNHL)的相关性.方法 36例先天性症状性CMV感染患儿,PCR法检测CSF CMV DNA载量,并于出生1个月内、生后6个月及1年左右行脑干听觉诱发电位检测.结果 (1)36例患儿,其中CSF CMV DNA阳性15例,阳性率41.2％,SNHL17例,SNHL发生率47.2％.(2) CSF CMV DNA阳性组SNHL发生率60.0％(9/15);阴性组SNHL发生率38.1％ (8/21),两组发生率比较差异无统计学意义(P =0.194).(3)CSFCMVDNA阳性组中,SNHL组与听力正常组CSF CMV DNA载量为3.35 ±0.68和3.17±0.56,两组载量比较,差异无统计学意义(P=0.36).结论 先天性症状性CMV感染患儿CSF CMV DNA是否阳性及其载量不是预测SNHL的指标.
Objective To determine the relationship between the viral load of cerebrospinal fluid (CSF) and sensorineural hearing loss (SNHL) in newborns with symptomatic congenital cytomegalovirus (CMV) infection.Methods The study cohort comprised 36 newborns with symptomatic congenital CMV infection.CSF from all of the patients were analyzed for the presence of CMV DNA by PCR.Audiological function were performed on them by brain stem auditory evoked potential at birth,at 6 and 12 months of age.Results (1)Of the 36 newborns,15 cases (41.7％) had positive CSF PCR result,17 cases (47.2％) had SNHL.(2) The prevalence of SNHL in the group of newborns with positive CSF PCR result was 60.0％ (9/15),and it was 38.1％ (8/21) in the group of newborns with negative CSF PCR result,there was no significant difference of the prevalence of SNHL between the two groups (P =0.194).(3) In newborns with positive CSF PCR result,the amounts of CSF CMV DNA was not different between the newborns with SNHL and

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感音神经性聋是一种常见的致残性疾病,药物治疗仍然是重要手段,全身给药是目前主要的给药方式。然而,由于血-迷路屏障的存在,全身给药方式给予的药物在耳蜗中分布的浓度较低,一些药物甚至不能通过血-迷路屏障,因此,常规全身给药方式治疗感音神经性聋的效果欠佳。而内耳局部注射的方式可有效绕过血-迷路屏障,可望克服全身给药耳蜗中药物浓度分布过低的缺陷;同时,随着基因工程技术和细胞学技术的飞速发展,耳蜗局部基因转染及耳蜗干细胞植入技术也被运用到感音神经性聋防治的研究中。本文将就内耳局部药物注射、局部基因转染及干细胞植入防治感音神经性聋的现状及展望进行综述。
Sensorineural hearing loss is a common disabling disease. The main therapy against this disease in the pres-ent age is that medication is administered via systemic application. However, due to the blood- labyrinth barrier, the concen-tration of drug performs low level when it is administered through systemic application, which causes low therapeutic effect against sensorineural hearing loss. This defect could be averted to large extent via local application, through which the blood-labyrinth barrier is bypassed. In the meantime, along with the developments the technologies of genetic engineering and cytology, local gene transfection and stem cell implantation are applied in the researches of treatments for sensorineural hear-ing loss. This review will examine the mechanism and the potential of therapeutics against sensorineural hearing loss via local application in cochlea.

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目的对急性低频感音神经性聋治疗效果进行研究,以探讨其发病机理.方法159名急性低频感音神经性聋分为2 组,分别采用改变咽鼓管功能及营养神经扩血管两种不同治疗方案进行治疗,研究不同治疗方法的治疗效果.结果二种方法均有良好的疗效,症状疗效评估和听力学疗效评估无统计学差异p（0.05）.结论急性低频感音性聋患者更多的应考虑是中耳病变导致的听力学检测低频骨导听阈上升的可能,同时也要警惕是否有内耳病变.
To study the theraputic effect and pathogenesis of acute low-frequency sensorineural hearing loss. 159 acute low-frequency sensorineural hearing loss patients participated in this study and divided into two groups, one group was received the treatment of improving eustachian tube function ,the other was received the treatment of vasodilator and neurotrophic,and we compared the effect of different methods. Both methods have good effect.There was no difference in clinical symptoms efficiency and hearing efficiency between two groups p(0.05). The pathogenesis of acute low-frequency sensorineural hearing loss should more consider the rising of low frequency conduction threshold caused by middle ear disease, but also to be alert to the inner ear disease.

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探讨重度感音聋患儿人工耳蜗植入术前心电图检查失败的原因和制定相应的护理对策的措施。方法:回顾性分析我院2011年2月~2012年2月期间收治行人工耳蜗植入术重度感音聋患儿428例(男236例,女192例)术前的临床资料和心电图,统计、分类及分析重度感音聋患儿术前心电图检查失败病例的失败原因,制定相应的护理对策。结果:术前心电图检查一次成功的患儿有188例,占44%;二次成功的患儿有232例,占54.2%;三次成功的患儿有8例,占1.87%;428例中有6例确诊为长QT综合征,不能手术。失败原因:(1)患儿家长及较大患儿对术前心电图检查的必要性及重要性缺乏了解。(2)对心电图检查前服用药物的作用及副作用不了解。(3)环境因素和患儿自身因素。结论:患儿家长遵医行为差,未完全按医嘱对患儿实施对术前心电图检查前的准备;重度感音聋患儿人工耳蜗植入术心电图检查前有针对性对患儿家长及患儿进行护理干预是必要的。
Objective:To investigate severe sensorineural hearing loss in children with cochlear implants before ECG failure and develop appropriate nursing measures. Methods:A retrospective analysis of our hospital in February 2011~February 2012 period 428 cases (236males, 192females) with severe sensorineural hearing loss in children with cochlear implants preoperative clinical and ECG data, statistics, analysis and classification severe sensorineural hearing loss in children with preoperative ECG failure cases causes of the failure to develop nursing measures. Results:Preoperative ECG successful children with 188 cases, accounting for 44%;quadratic successful children with 232 cases, accounting for 54.2%;three successful children with eight cases, accounting for 1.87%;6 cases in 428 cases diagnosed with long QT syndrome, inoperable. Failure:(1) children with parents and children on a larger preoperative ECG lack of understanding of the necessity and importance. (2) ECG before taking on the role

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目的：分析多频稳态诱发电位评估中度感音神经性聋儿童的应用效果,以供参考。方法：以2009年9月~2012年8月在我院收治的中度感音神经性聋患儿62例为研究对象,分别进行多频稳态诱发电位检测(ASSR)和纯音听阈测试(PTA),比较两者不同频率下测试阈值的差异。结果：与PTA相比较,ASSR在0.5kHz、1.0kHz、2.0kHz、4.0kHz的测试阈值均较高,有显著的统计学差异(P<0.05)。其中0.5kHz频率下差异最大。结论：采用多频稳态诱发电位对中度感音神经性聋儿童进行听力评估,测试结果客观,可为患儿验配助听器、植入人工耳蜗提供客观依据。
Objective:Analyze multiple auditory steady-state evoked potential evaluation of application effect of moderate sensorineural deafness children,for reference.Methods:Choose 62 cases with moderate sensorineural deafness from Sep. 2009 to Aug. 2012 in our hospital as research object,were detected by auditory steady-state evoked potentials (ASSR) and pure tone audiometry (PTA) test,compare the difference threshold under different frequencies the two methods.Results:Compared with PTA and ASSR,1.0kHz,0.5kH z,2.0kHz,4.0kHz in the test threshold were higher,with significant statistical difference (P<0.05).The frequency of 0.5kHz is the biggest difference.Conclusion:ASSR for hearing evaluation of moderate sensorineural deafness children,test result is objective,can provide objective basis for children with hearing aid fitting,or implant artificial cochlea.

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目的分析一个连续5代遗传的常染色体显性遗传性聋家系的临床听力学及遗传学特征。方法对一个常染色体显性遗传高频感音神经性聋家系成员进行全面体检及临床听力学检查,整理、分析家系资料,确定遗传规律,绘制遗传图谱并进行听力学特征分析。应用Sanger测序技术对该家系成员进行候选基因鉴定。结果该耳聋家系遗传方式为常染色体显性遗传,发病年龄各代间较稳定,在30-45岁之间。听力学表型为代代相传、迟发性、渐进性的中度至重度听力损失,患者早期以高频听力下降为主,随着年龄增长逐渐累及全频听力。应用Sanger测序技术进行候选基因鉴定,未发现致聋突变位点。结论该家系遗传学特征符合常染色体显性遗传方式,听力学具有早期高频听力下降并逐渐累及全频的特征,在候选基因中进行测序未发现致聋突变位点。因此希望通过对家系进一步的表型分析或者运用新一代测序技术,可以找到该家系的致聋基因。
Objective To investigate the clinical and genetical characteristics of a Chinese family with an autoso-mal-dominant inherited sensorineural hearing loss. Method This pedigree associated with an autosomal-dominant inherit-ed high-frequency sensorineural hearing loss was investigated. All study participants medical and detailed audiological exam-ination was performed. Candidate genes were accepted verification by Sanger sequencing. Result A Chinese family XS-512 with nonsyndromic autosomal dominant hearing loss was ascertained. The affected members showed postlingual, progressive, bilateral moderate to severe sensorineural hearing loss. The age of onset varied from 30 to 45 years. The audiograms was se-vere at the high frequencies early, lower frequencies became involved with increasing age, and gradually accumulated all fre-quencies of hearing. Candidate genes were preliminary excluded by Sanger sequencing. Conclusion Pedigree analysis sug-gested an autosomal-dominant inheritance patter

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目的：分析了解国内对针灸治疗感音神经性聋的研究状况。方法检索获得2002年1月～2011年12月有关针灸治疗感音神经性聋的文献141篇，进行分析评价。结果动物实验研究11篇，占7.80%，临床研究130篇，占92.20%，其中临床描述性研究51篇，占36.17%，病例对照研究79篇，占56.03%。临床研究病种主要为突发性聋，占66.92%，治疗方法主要为针刺治疗，多数文献有明确的诊断标准及疗效标准，只有5篇文献提到随访。结论针灸治疗感音神经性聋属于快速发展阶段，但其疗效有待高质量试验进一步证实。
Objective To analysis and understand the survey of studies on the treatment of acupuncture and moxibustion on sensorineural deafness in china. Method Collecting and analyzing the Chinese documents about the treatment of acupuncture and moxibustion on sensorineural deafness in the latest 10 years,which is from Jan. 2002 to Dec. 2011. Result The main contents and their percentages were as follows: animal study accounted for 7.80%, descriptive clinical studies accounted for 36.17% and clinical case - control study accounted for 56.03% .The disease for clinical studies were mainly sudden deafness(66.92%), and the treatment methods were acupuncture therapy,. Most papers have definite diagnostic standard and the therapeutic effects standard. Only 5 papers mentioned the follow-up. Conclusion The therapeutic effects of acupuncture and moxibustion on sensorineural deafness need to be confirmed with studies of higher quality.

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为了进一步提高云南省保山市中医院治疗感音神经性耳聋耳鸣的临床疗效,本文就中西医联合治疗感音神经性耳聋耳呜的临床效果进行了浅显的研究和探讨。方法:选择云南省保山市中医院自2012年12月-2013年12月期间收治的96例感音神经性耳聋耳呜患者,平均分为观察组和对照组,各48例,对照组行西医治疗,观察组患者行中西医联合治疗,对两组患者的治疗效果及不良反应发生情况进行观察和统计。结果:观察组患者治疗的总有效率明显高于对照组患者(P0.05);观察组患者不良反应发生率明显低于对照组患者(P0.05)。结论:中西医联合治疗感音神经性耳聋耳鸣的临床效果显著,有效提高了患者的生活质量,值得推广。
Objective: To study clinical effects of the integrative medicine on sensorineural deafness and tinnitus. Methods: 96 patients were randomly divided into two groups, the control group was given western medicine, and the observation group was given the integrative medicine. Results:The total efficacy in the observation group was obviously higher (P<0.05);the adverse reactions rate in the observation was lower (P<0.05). Conclusion:The integrative medicine was effective on sensorineural deafness and tinnitus, can improve quality of life, and worthy of promotion.

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