儿科临床中我们常见的感染症状基本都是病毒引起的，但是现在我们还没有研制出非常有效的抗病毒药物。干扰素的问世填补了这一项的空白，干扰素被证实具有广谱抗病毒、抗肿瘤和免疫调节作作用。重组人干扰素a-1b是一种采用健康人白细胞来源的干扰素基因克隆和表达的基因工程干扰素，由于其疗效显著、副作用低、不易产生中和抗体等优点，近年来已逐渐在临床上得到了应用。目前我国严格控制使用抗生素，病毒性感染疾病使用干扰素，可以减少滥用抗生素，在儿科有广泛的应用。本文主要综述干扰素在儿科常见几种病中的应用。

Is caused by a virus infection symptoms we arecommon clinical pediatrics, but now we have not yet developed a very ef ective antiviral drug. Interferon hasfil ed the blank of this item, interferon was confirmed with broad-spectrum anti-virus, anti-tumor and immune regulation function. Recombinant human interferon a-1b isgenetic engineering interferon and an expression of thehealthy human leukocyte derived interferon gene cloning,because of its remarkable curative ef ect, low side ef ect, not easy to produce such antibodies to neutralize theadvantages, in recent years it has gradual y been appliedin clinical. At present, strictly control the use of antibiotics, viral infection, the use of interferon, can reduce the abuse of antibiotics, is widely used in pediatrics. This article reviews the application of interferon in several common disease in pediatrics.

干扰素调节因子8作为干扰素调节因子家族成员,在肿瘤发生以及抗肿瘤免疫中发挥着重要的作用。该文对干扰素调节因子8在肿瘤中的研究进展进行综述。

As a member of IRFs family ,IRF8 plays an important role in the oncogenesis and antitumor immunity .In the present review , we aim at summarizing our current knowledge of the roles of IRF 8 in the regulation of oncogenesis .

就猪α-干扰素的分子特征、生物学特性、表达系统和猪基因工程α-干扰素的应用进行综述,以期为猪α-干扰素在广谱抗病毒活性、抗肿瘤以及免疫调节的临床应用提供参考。

Porcine interferon- α has broad spectrum anti-virus activity, anti-tumor activity and immune regulation action. The molecular characteristics, biological characteristics, expression system and the application of genetic engineering of porcine interferon- α were reviewed in this article in order to provide reference for its clinical application.

目的 研究干扰素类型及丙肝病毒载量对慢性丙型肝炎抗病毒治疗应答的影响.方法 选择297例慢性丙型肝炎患者为研究对象,对抗病毒治疗的应答情况与干扰素类型及丙肝病毒载量的关系进行回顾性分析.结果 在HCV RNA≥105 IU/ml组,聚乙二醇干扰素α-2a抗病毒治疗获得快速病毒学应答(RVR)率为74.7％,早期病毒学应答率(EVR)为81.6％,普通干扰素α-2b组RVR获得率为58.7％,EVR获得率为62.5％,组间比较差异有统计学意义(P＜0.05).而在HCVRNA＜105 IU/ml组,聚乙二醇干扰素α-2a组获RVR率为80.9％,EVR率为88.2％,普通干扰素α-2b组获RVR率为80.6％,EVR率为85.5％,组间比较差异无统计学意义(P＞0.05).结论 在病毒载量较高的情况下,聚乙二醇干扰素α-2a针较普通干扰素α-2b针抗病毒治疗的RVR及EVR获得率高.而在病毒载量较低的情况下,聚乙二醇干扰素α-2a针与普通干扰素α-2b针抗病毒治疗的RVR及EVR获得率差异无统计学意义.

Objective To investigate the effect of interferon types and hepatitis C viral load on anti-viral treatment response of chronic hepatitis C.Methods The clinical data of 297 chronic hepatitis C who received antiviral treatment was studied,the correlation of response condition with interferon types and hepatitis C viral load was retrospectively analyzed.Results In HCV RNA above 105 IU/ml case,pegylated interferon α-2a received RVR was 74.7％,EVR was 81.6％,ordinary interferon α-2b received RVR was 58.7％,EVR was 62.5％.In HCV RNA below 105 IU/ml case,pegylated interferon α-2a received RVR was 80.9％,EVR was 88.2％,ordinary interferon α-2b received RVR was 80.6％,EVR was 85.5％.Conclusions When HCV RNA load was higher,pegylated interferon α-2a received higher rapid virological rate and early virological response than ordinary interferon α-2b.When HCV RNA load was lower,interferon type response to antiviral therapy was not statistically significant.

目的：观察手足口患儿免疫功能改变及其黄芪注射液及干扰素的免疫调节作用。方法收集手足口神经系统受累期患儿58例，随机分为对照组28例，黄芪联合干扰素治疗组30例，两组均给予基础治疗，联合治疗组加用黄芪注射液及重组人干扰素α-2b注射液，观察患儿一般情况改变并检测治疗过程中患儿细胞及体液免疫功能变化，评价黄芪注射液及干扰素的联合治疗作用。结果黄芪联合干扰素治疗组神经系统症状缓解时间、热程及疗程均较对照组短，差异有统计学意义（P＜0.05）；治疗3d时，对照组CD3、CD4、IgM较治疗前差异有统计学意义(P＜0.05)。与治疗前及对照组比较，黄芪联合干扰素治疗组免疫指标差异均有统计学意义(P＜0.05)。结论黄芪注射液联合干扰素可有效治疗手足口病，机制与免疫调节相关。

Objective To observe the immune function changes of HFMD and immunomodulatory ef ects of Astragalus injection combined with interferon. Methods fifty-eight cases of HFMD children in nervous system involvement stage were divided into 2 groups (28 cases in control group and 30 cases in Astragalus combined with interferon treatment group).Two groups were given basic treatment, and the treatment group were treated with Astragalus injection and interferon alfa-2b injection.To observer the general conditions and changes of cellular and humoral immune function in children,and evaluate the therapeutic ef ect of Astragalus injection and interferon. Results The dif erence was statistical y significant between the two groups in nervous system symptoms releif time and the process of heat and treatment (P< 0.05); at the 3 day of treatment, the CD3, CD4, IgM in control group had significant dif erence compared with those before treatment (P<0.05). Compared with control group and before treatment,al