目的:探讨原发性高血压病患者动态脉压参数与颈动脉粥样硬化的关系。方法对61例原发性高血压病患者进行24 h动态血压监测及颈动脉超声检查,将其分为动脉硬化组40例与非硬化组21例。比较2组中的24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、白昼脉压(dPP)、夜间脉压(nPP)及动态脉压(APP)。再将其按靶器官损伤程度分为A、B、C 3组,比较其上述APP参数。结果动脉硬化组24 h SBP、dPP、nPP及APP较非硬化组显著升高和增大(P<0.05),24 h DBP 2组间比较差异无统计学意义。随着靶器官损伤程度的加重,动态脉压参数也不同程度增大。结论原发性高血压病患者APP增大及收缩压升高与颈动脉硬化密切相关,是导致靶器官损伤的重要原因。
Objective To study the relationship between the ambulatory pulse pressure (APP) related indexes and ather-ogenesis in hypertensive patients. Methods The 24 hours ambulatory blood pressure monitoring and carotid ultrasonic testing were performed on sixty-one patients with hypertension. All the patients were divided into two groups:arterio-sclerotic group(n=40), non-arteriosclerotic group(n=21). 24 h SBP, 24 h DBP, dPP, nPP and APP were com-pared between the two groups, All the patients were divided into three groups (GroupA, GroupB, GroupC) according tothe damage degree of target organ. Twenty-four SBP, 24 h DBP, dPP, nPP and APP were compared in three groups. Results Twenty-four SBP, dPP, nPP and APP of arteriosclerotic group were significantly higher than those of non-arteriosclerotic group (P<0.05). It was no significant differerece in 24 h DBP between the two groups. As the damage degree of target organs went to be deeper and deeper, the parameter of dPP increased by diffe