目的 评价蚊孳生水体周围居民疟疾休止期划范围服药措施对疟疾的控制效果.方法 采用分层整群随机抽样法,于2007年3月选取淮河沿岸及其以北地区疟疾高发的6个县,每县根据2006年病例数将自然村分为5层,每层抽取1个自然村,即每县抽取5个自然村,共抽取30个自然村.每个自然村调查300 ~500名对象,合计12 860名.将每个县的5个自然村按区组随机化法分配到3个处理组中,其中,干预1组有9个自然村,4362名调查对象;干预2组有12个自然村,4471名调查对象;非干预组有9个自然村,4027名调查对象.应用问卷调查研究对象基本情况.调查疟疾病例与蚊孳生水体分布的关系,并以此作为划范围服药的依据.对干预1组采取划范围服药措施,对干预2组采取常规服药策略,非干预组不实施干预策略.计算2006、2007年各组研究对象疟疾发病率、标化发病率、发病率净变化值(干预前后标化发病率差值)、年龄别发病率,以及划范围服药措施的保护率、效果指数和病例捕获率.结果 干预1组共服药1219名(占27.9%),干预2组共服药219名(占4.9%).2006年干预前,干预1组、干预2组和非干预组分别以50 ~59岁、60 ~69岁和70岁以上年龄组发病率较高,其发病率分别是36.22‰(18/497)、40.11‰(15/374)和34.88‰(9/258).干预后,
Objective To evaluate the effect of preventive medicine for residents living around mosquito breeding water during rest period of malaria by delimiting a certain range.Method The study adopted the stratified cluster random sampling method to select subjects from 6 counties in the high epidemic area along and north of the Huai River since March 2007.Then the villages of 6 counties were stratified into five levels according to the case reported in year 2006,and one village was randomly selected from each level,thereby 30 villages were selected in total.300-500 subjects were interviewed in each village,and in total 12 860 subjects were recruited in the study.The five selected villages in each county were allocated to three intervention groups according to the block randomization method.The first intervention group included 9 villages,4362 people; the second intervention group was consisted of 12 villages,4471 people; the non-intervention group had 9 villages,4027 people.The basi