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双语推荐：索菲

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文章运用弗洛伊德关于人的人格结构理论,分析了《岛》中索菲娅的人物性格由"本我"而"自我"到"超我"的嬗变过程。通过对索菲娅的矛盾性格的分析,启示文学合乎逻辑地描写复杂性格的重要意义及其价值。
This article uses Freud''s Personality Structure theory to analyze Sophia''s character in “The Island".It analyzes the social and physiological reasons of her disposition ’s conversion from the early time’s self-confidence ,to slow self-esteem and finally introversion in the later period .So this paper show s the significant meaning and value of contrary disposition .

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目的：研究索拉菲尼对肝星状细胞（HSC）活性及活化的影响及作用机制。方法：分别将1、2、5、10μmol/L索拉菲尼培养液作用于LX2细胞,通过MTT检测观察不同浓度索拉菲尼对LX2细胞增殖的影响,应用免疫细胞化学染色法检测LX2细胞α-SMA的表达,ELISA法检测LX2细胞上清中PDGF-BB和TGF-β1水平变化,Western blot法检测各组LX2细胞PDGF信号通路各蛋白表达情况。结果：各组、各时间点LX2细胞增殖抑制率比较,差异均有统计学意义（F组间=1 045.010,F时间=279.740,F交互=20.130,P均〈0.001）。各组α-SMA的表达情况比较,差异有统计学意义（H=35.630,P〈0.001）。各组、各时间点PDGF-BB和TGF-β1水平比较,差异均有统计学意义（P均〈0.05）。实验组与对照组中ERK1、ERK2、AKT的表达基本相同,但在10μmol/L索拉菲尼干预后,各磷酸化蛋白表达降低。结论：索拉菲尼可抑制HSC的增殖及活化。
To investigate effects and mechanisms of sorafenib on hepatic stellate cell ( HSC) viability and acti-vation.Methods:LX2 cells were cultured with 1,2,5,10 μmol/L sorfenib and detected with MTT assay at different timerespectively .Expression of α-SMA was measured immunocytochemically in LX 2 cells treated with different concentrations of sorafenib.Changes in PDGF-BB and TGF-β1 concentrations were detected in LX2 supernatant using ELISA .Expression of ERK1 , ERK2 and AKT signaling pathways was measured using Western blot assay .Results:After treatment with various concentrations of sorafenib for different times , the LX2 inhibition rate increased gradually ( Fgroup =1 045.010, Ftime =279.740,Finteraction =20.130,P<0.001).α-SMA expression treated with sorafenib became weaker than that in control group(H=35.630,P<0.001).PDGF-BB and TGF-β1 concentrations decreased with the increasing of sorafenib concen-tration and time exposured(P<0.05).ERK1, ERK2 and AKT expression was iden

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索拉菲尼是一种口服多激酶抑制剂。通过作用于Raf激酶直接抑制肿瘤细胞增殖，还可作用于血管内皮生长因子受体1，2，3（VEGFR-1，-2，-3），以及血小板源生长因子受体-B（PDGFR-13）、受体酪氨酸激酶、抑制肿瘤新生血管生成。索拉菲尼通过抑制肿瘤细胞增殖和抗血管生成的双重作用，从而达到抗肿瘤的目的。已被多个国家批准作为首个系统治疗肝细胞肝癌的分子靶向药物。其常见不良反应包括皮肤反应、恶心、腹泻、体质量减轻、高血压等，影响了患者的长期使用依从性，进而影响治疗效果。正确地认识和管理索拉非尼的不良反应则有助于发挥索拉非尼的治疗作用，提高临床效果。本文从索拉菲尼靶向治疗的常见不良反应、发生机制及处理方法等方面进行综述。
Sorafenib is a novel oral multikinase inhibitor that inhibits Raf kinase because of its anti-proliferative property. Sorafenib also inhibits receptor tyrosine kinases of multiple proangiogenic factors, such as VEGFR-1/2/3 and PDGFR-β. The combina-tion of both its anti-proliferative and anti-angiogenic properties makes sorafenib an attractive agent in cancer treatment. To date, sorafenib is the only approved systemic treatment for patients with hepatocellular carcinoma. The most common adverse events of this inhibitor included hand-foot skin reactions, nausea, diarrhea, weight loss, and hypertension. These adverse events can severely affect patient compliance, which may negate the effect of therapy. Correct understanding and treatment of these adverse events can improve clinical outcome. This paper discusses the clinical aspect of sorafenib-induced adverse events and the molecular basis behind their toxic-ity. Recommendations for the management of the adverse effects are also provided.

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目的探讨甲胎蛋白(AFP)在索拉菲尼治疗进展期肝细胞肝癌中的作用和临床意义,以及索拉菲尼临床毒副作用。方法回顾性分析2009年8月至2012年8月应用索拉菲尼治疗的45例无法手术切除的原发性肝细胞癌病例临床资料。将其分为AFP应答组和无应答组,分析其与临床预后的关系。按照癌症研究所常见毒性反应标准对药物不良反应进行评价和分级。结果本组患者随访2~24个月。AFP应答组患者疾病控制率(CR+PR+SD)为61.1%;AFP无应答组疾病控制率为51.8%。AFP应答组和无应答组中位总生存期分别为13.5个月和8个月。多因素分析显示,AFP应答、肝炎、TNM分期及静脉侵袭是影响肝癌患者总生存期的独立危险因素。常见药物毒性反应为手足皮肤反应、相关胃肠道反应(包括恶心、呕吐、腹泻、口腔黏膜炎)和脱发。结论索托菲尼治疗晚期原发性肝细胞癌,在AFP应答组效果较好,用药前肝炎情况、TNM分期及静脉侵袭可能对预测索托菲尼的疗效有帮助。
Objective To investigate the usefulness of AFP response in sorafenib therapy patients with advanced hepatocellular carcinoma. Methods Forty-five patients who received sorafenib therapy with unresectable or metastatic HCC were included in this study from Aug 2008 to Aug 2012. Patients were set up into two groups according to the response of AFP. The relationship between different clinical variable factors and curative effects of sorafenib was analyzed by using Cox proportion hazard regression analysis and the side effects were also estimated. Results Of these cases, Fifteen patients in the AFP response group had tumor progression and 14 died , the disease control rate was 61.1%,while 21 patients in the AFP non-response group had tumor progression and 18 died ,.the disease control rate was 51.8%. The median time to overall survival time was 13.5 months and 8 months (P<0.05) in AFP response group and AFP non-response group, respectively. Multivariate analysis showed that AFP response,cirr

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研究目的：应用磁共振弥散加权成像（DWI）监测荷瘤裸鼠肝细胞性肝癌表观弥散系数（ADC）的变化，探讨ADC对索拉菲尼治疗肝细胞性肝癌的疗效预测。创新要点：探讨磁共振DWI对索拉菲尼治疗肝癌疗效的早期评估，期望能够指导临床合理用药。研究方法：荷瘤裸鼠分成两组（治疗组和对照组）共40只，使用GE 3.0T磁共振成像系统和小动物线圈，分别于服药前后1、10、14和18天（40 mg/kg，一天两次）进行T1加权成像（T1WI）、T2加权成像（T2WI）和DWI扫描。在弥散加权图像上进行ADC测量，对比不同区域和不同时间点的差异。重要结论：索拉菲尼治疗10天后，伴随肝癌肿瘤的缩小，肿瘤内部ADC值明显上升，病理切片显示治疗组瘤体中心小血管闭塞，凋亡细胞可见，此时瘤体内坏死细胞并未大量显现，说明 ADC值的改变可以反映索拉菲尼的疗效。
Objective: The relationship between apparent diffusion coefficient (ADC) and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma (HCC) has not been demonstrated. This study was to investigate the ADC changes of ad-vanced HCC under sorafenib treatment. Methods:Athymic mice with HepG2 xenografts were al ocated to two groups:control and sorafenib (40 mg/kg, bid). T2 and diffusion images were acquired at each time point (0, 10, 14, and 18 d post-therapy). Tumor volume and changes in ADC were calculated. Results:Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control grou

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目的：对比索拉菲尼单药与联合应用肝动脉栓塞化疗术（ TACE）、经皮局部氩氦刀消融（PLCT）综合治疗失去手术机会的肝癌的治疗效果。方法回顾性分析64例无法手术切除的肝癌患者的临床资料，行索拉菲尼单药或索拉菲尼联合 TACE、PLCT 治疗。其中索拉菲尼单药治疗32例，联合介入和氩氦刀消融治疗32例，随访时间6~32个月，观察两组患者治疗效果和肿瘤进展时间。结果所有患者顺利完成治疗，无手术相关死亡及严重并发症。64例患者中，完全缓解（ CR）11例，部分缓解（PR）31例，稳定（SD）14例，进展（PD）8例，其中单药治疗组 CR 3例，PR 11例，SD 12例，PD 6例；联合介入和氩氦刀消融组 CR 8例，PR 20例，SD 2例，PD 2例，两组比较差异有统计学意义（χ2=14.028，P=0.003）。中位肿瘤进展时间分别为20周和53周，两组比较差异有统计学意义（χ2=14.773，P=0.000）。结论针对无法手术切除的肝癌，索拉菲尼联合 TACE 和 PLCT 治疗效果较好，可延长肿瘤进展时间。
Objective To investigate the efficacy of sorafenib alone or combination with transarterial chemoembolization(TACE)and percutaneous local cryotherapy(PLCT)for advanced hepatocellular carcinoma patients without operation opportunity. Methods Sixty-four advanced hepatocellular carcinoma patients were selected as our subjects,who were underwent treatment of sorafenib alone or combination with TACE and PLCT. Thirty-two cases with sorafenib therapy were served as sorafenib group and another 32 cases with sorafenib in combination with transarterial chemoembolization and PLCT were served as combination group. All patients were followed up for 6 - 32 months. The treatment efficacy and tumor development were recorded. Results All surgeries of the patients were succeed and no death or serious operation complications occurred. Of 64 patients, 11 were achieved a complete remission( CR),31 cases with partial remission( PR),14 cases with stable development(SD),and 8 cases with progressive disease(PD)

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小说《达·芬奇密码》是美国著名作家丹·布朗的代表作。《纽约时报》畅销书作者克莱夫·库斯勒称赞小说《达·芬奇密码》为一部神话。小说《达·芬奇密码》不仅是一部神话,也是一部童话。小说《达·芬奇密码》中的童话模式也给读者留下了深刻的印象。在丹·布朗用文字编写的美丽童话中,索菲·奈芙是一名美丽而聪明的公主。而罗伯特·兰登则是一名机智的王子。罗伯特·兰登冒着生命危险去保护索菲·奈芙。
"The Da Vinci code"is a famous American author Dan brown''s masterpiece. The New York times best-selling author Clive, le praised the novel"the Da Vinci code"is a myth."The Da Vinci code"is a myth, not only is a fairy tale."The Da Vinci code"in the fairy tale mode also left a deep impression on the readers. Dan brown''s beautiful fairy tale written in words, Sophie Neveu fu is a clever and beautiful princess. And Robert Langdon is a wit of the prince. Robert Langdon, risking his life to protect Sophie Neveu.

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目的探讨索拉非尼联合表阿霉素、氟尿嘧啶治疗原发性肝癌的临床疗效和安全性。方法回顾性分析我院自2003年2月~2010年2月收治的56例原发性肝癌患者,随机分为治疗组及对照组各28例。治疗组:索拉菲尼联合EF方案;对照组单用索拉菲尼,比较两组的总体疗效及不良反应发生率。结果治疗组在有效率、疾病控制率、中位无进展生存时间、中位生存期、1年生存率均优于对照组,差异有统计学意义(P0.05);两组的主要不良反应均为疲乏、高血压、手足皮肤反应、腹泻等,治疗组较对照组除了白细胞减少及恶心、呕吐略差外(P0.05),两组间其他不良反应差异无统计学意义(P0.05)。结论索拉非尼联合(EF方案)化疗治疗原发性肝癌的近期疗效高,安全性好,患者耐受性好,值得临床进一步研究。
Objective To observe the clinical efficacy and safety of sorafenib combined with chemotherapy for hepatocellular carcinoma. Methods 56 patients with Hepatocelular Carcinoma admitted in our hospital from February 2003 to February 20l0,were randomly divided into the treatment group and the control.The treatment group was interfered with sorafenib combined with EF;The control group was treated with sorafenib. Overall efficacy and incidence of adverse reactions were compared. Results The treatment group is more efficacy than the control group in The effective rate (CR+PR),control rate,median follow-up time,median progression-free survival (PFS),median survival (OS)and 1 year survival rate is better in treatment than those in the control,The difference was statistically significant (P 0.05). Conclusion Sorafenib combined with (EF program) chemotherapy was more efficacy,safety,and well tolerated in the treatment of HepatocelIular Carcinoma.

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以昆钢科技大厦(索菲特酒店)为例,介绍了建筑、结构和机电专业在应对绿色建筑时的各种设计策略,探讨了绿色建筑技术在超高层五星级酒店和办公综合体中应用的各种可能性,为绿色建筑技术的推广指明了方向。
Taking Kungang Science and Technology Mansion（Sofitel Hotel） as the example,the paper introduces the all kinds of design strategies of the green buildings from the architecture,the structure and electromechanical specialties,and explores all sorts of possibilities for the green building technique in the super-high-rise five-star hotel and office integrated buildings,so as to provide the direction for extending the green architectural technique.

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《达·芬奇密码》是美国著名作家丹·布朗的重要作品。小说《达·芬奇密码》中索菲·奈芙的善良、罗伯特·兰登的无私以及勇敢,与曼努埃尔·阿林加洛沙主教的自私、雷·提彬爵士的残忍以及雷米·莱格鲁德的贪婪形成鲜明对比,给读者留下深刻印象。
The Da Vinci Code is Dan Brown’s important book. Dan Brown is a famous writer in the United States. In The Da Vinci Code,Sophie Neveu’s kindness,Robert Langdon’s unselfishness and bravery form a kind contrast with Manuel Aringarosa’s selfishness,Sir Leigh Teabing’s cruelty and Rémy Legaludec’s greed,which leaves a deep impression on the readers.

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