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双语推荐：奈达

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目的：探讨替吉奥＋奈达铂、多西他赛＋奈达铂方案加同步放疗治疗中晚期食管癌的疗效及不良反应。方法56例中晚期食管癌患者随机分为替吉奥＋奈达铂组28例和多西他赛＋奈达铂28例。两组患者放疗均与化疗同步。结果替吉奥＋奈达铂、多西他赛＋奈达铂组有效率分别为82.1%、85.7%，两组比较差异无统计学意义（P 〉0.05）。主要不良反应为消化道反应、骨髓抑制、放射性气管炎、放射性食管炎、静脉炎。多西他赛＋奈达铂组骨髓抑制较重，两组间比较差异有统计学意义（P 〈0.05）。经对症处理后患者可以耐受，无治疗相关性死亡。结论两方案同步放化疗治疗均可用于中晚期食管癌的综合治疗，替吉奥＋奈达铂组毒不良反应轻。
Objective To investigate the efficacy and safety of S-1 combined with nedaplatin,do-cetaxel combined with nedaplatin plus concurrent radiotherapy in the treatment of moderate and advanced stages of esophageal cancer. Methods Fifty-six patients with the moderate and advanced stages of esopha-geal cancer were randomly divided into two groups:S-1 combined with nedaplatin,docetaxel combined with nedaplatin plus concurrent radiotherapy. Results The effective rate in the S-1 combined with nedapl-atin group and the docetaxel combined with nedaplatin group was 82. 1% and 85. 7%,the difference was not statistically significant. The main side effects were gastrointestinal reactions,myelosuppression,radio-active bronchitis,radioactive esophagitis,phlebitis. Docetaxel combined with nedaplatin had more the heavier myelosuppression,but it could be controlled after treatment. Conclusions Two concurrent chemo-radiation therapy program can be used. S-1 combined with nedaplatin has light toxic

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阐述了奈达的语言文化观，从“形式对等”“动态对等”“功能对等”三个方面系统而全面地分析了奈达对等翻译理论的基本观点。论述了翻译界对奈达对等翻译理论的种种反应以及该理论在翻译实践中的应用，认为将奈达的对等翻译理论应用于中英双语新闻翻译中，将是一个值得研究与探讨的课题。
Based on the expounding of Nida’s concepts of language and culture,this paper analyzes the bas-ic concepts of Nida’s theory systematically and completely through three aspect of “formal equivalence”,“dynamic equivalence”,and “functional equivalence”,expounds the responses of scholars from translation circles and the application of the theory in the practices,and points out that the application of Nida’s theo-ry in Chinese-English news translation is a deserving topic.

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目的对比分析低剂量奈达铂或低剂量顺铂联合放疗2种方案在治疗中晚期食管癌的临床疗效和毒副反应。方法 100例中晚期食管癌患者随机分为2组,奈达铂组50例接受低剂量奈达铂联合三维适形放疗,顺铂组50例接受低剂量顺铂联合三维适形放疗。结果奈达铂组有效率为80.0%,高于顺铂组的60.0%(P0.05)。恶心、呕吐发生率奈达铂组低于顺铂组(P0.05)。结论低剂量奈达铂联合三维适形放疗治疗中晚期食管癌相比顺铂具有高效低毒的优势。
Objective To compare the effect and toxicities of low-dose nedaplatin or cisplatin combined with three dimensional conformal radiation therapy for advanced esophageal cancer. Methods One hundred patients with advanced esophageal cancer were divided randomly into two groups,50 patients of the nedaplatin group received the low-dose nedaplatin combined with three dimensional conformal radiation therapy and 50 patients of the cisplatin group received the low-dose cisplatin combined with three dimensional conformal radiation therapy. Results The response rate was 80. 0% in the nedaplatin group,and was 60. 0% in the cisplatin group(P < 0. 05). The inci-dence of nausea and vomiting of the nedaplatin group was significantly lower than that of the cisplatin group(P <0. 05). Conclusion Compared with low-dose cisplatin combined with three dimensional conformal radiation thera-py,low-dose nedaplatin combined with three dimensional conformal radiation therapy has the better efficacy and lighter tox

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比较培美曲塞二钠或吉西他滨联合奈达铂治疗晚期非小细胞肺癌(NSCLC)的临床疗效及毒副作用。方法:将80例晚期NSCLC按随机数字表法分为吉西他滨加奈达铂组(GN)40例和培美曲塞二钠加奈达铂组(PN)40例。GN组给予吉西他滨1000 mg/m2,d 1,8;奈达铂80 mg/m2,d 2。PN组培美曲塞二钠500 mg/m2,d 1;奈达铂80 mg/m2,d 2,两组均为每21天为一个周期重复,完成2个周期后进行评价。结果:PN组有效率为42.5%,GN组为40.0%,差异无统计学意义(P0.05);PN组骨髓抑制发生率小于GN组(P0.05)。结论:培美曲塞二钠联合奈达铂治疗晚期非小细胞肺癌的疗效与吉西他滨加奈达铂的疗效相当,但副作用明显减少,可以作为临床一线治疗。
Objective:To observe the efficacy and toxicity of Pemetrexed or Gemcitabine plus Nedaplatin(NDP) in treatment of patients with advanced non-small cell lung cancer(NSCLC).Method:80 patients with late stage NSCLC were enrolled into this study.These patients were divided into the GN group(Gemcitabine plus Nedaplatin,n=40)and the PN group(Pemetrexed plus Nedaplatin,n=40). The GN group:Gemcitabine 1000 mg/m2 plus Nedaplatin 80 mg/m2;the PN group:Pemetrexed 500 mg/m2 plus Nedaplatin 80 mg/m2.The efficacy of patients received two cycles will be evaluated. Result:The effective rate in the GN groups was 40.0% and in the PN group was 42.5%,there was no statistically significant difference(P>0.05). Bone marrow inhibition rate of the PN group was less than the GN group(P<0.05). Conclusion:Pemetrexed plus Nedaplatin had the same effect as Gemcitabine plus Nedaplatin in treatment of patients with NSCLC,,but the side effects decreased significantly,it can be used as a first-line in the clin

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决奈达隆是治疗心房颤动的新药之一，本文就决奈达隆的药理特点及其6项Ⅲ期临床试验做一简述，为临床用药提供指导。
Dronedarone is one of the new drugs for the treatment of atrial fibrillation.This paper briefly introduces the pharmacological characteristics of dronedarone and 6 phase Ⅲ clinical trials, aiming to guide clinical medication.

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目的：探讨国产奈达铂联合或单药化疗过程中出现奈达铂致严重过敏反应患者的抢救和护理。方法回顾性分析2011年1月至2014年7月我科收治的肿瘤患者在使用奈达铂化疗过程中8例发生严重过敏反应的患者救治及护理。结果经医护人员及时发现与抢救，8例发生严重过敏反应的患者症状缓解，生命体征均恢复正常。结论奈达铂应用过程中易出现过敏反应，用药过程加强巡视，密切观察患者用药后的反应，及早发现，及时处理。
Objective?To?investigate?rescue?and?nursing?of?patients?with?severe?allergic?reaction?induced?by?nedaplatin?treated?with?domestic?nedaplatin?combination?or?single?agent?chemotherapy.?Methods?73?patients?emerging?adverse?events?during?treatment?with?nedaplatin?chemotherapy?was?enrolled?during?January?2011?to?July?2014?at?our?department.?Of?which?eight?patient?received?rescue?and?nursing?due?to?severe?allergic?reaction?were?summarized?and?analyzed.?Results?Eight?patient?with?severe?allergic?reaction?were?all?relief?and?recovered?after?timely?rescuing?and?nursing.?Conclusion?Nedaplatin?chemotherapy?was?widly?used?in?clinical?practice.?It?is?worthy?to?inquire?allergic?history?of?patient?and?necessary?to?educate?to?patient?because?of?high?incidence?of?allergic?reaction.?Inspection?to?patient?during?treatment?with?nedaplatin??chemotherapy?should?be?strengthened.?Close?observation?should?be?given?to?patient?after?received?nedaplatin?in?order?to?avoid?risk?and?ensure?patients’?safet

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目的观察紫杉醇与奈达铂联合化疗治疗晚期子宫内膜癌的疗效和毒副反应.方法32例晚期子宫内膜癌初治患者,17例接受紫杉醇+奈达铂(TP组)方案,同期接受 CAP(环磷酰胺+阿霉素+顺铂)方案(CAP 组)15例进行比较.结论紫杉醇联合奈达铂治疗晚期子宫内膜癌依从性好,毒副反应可以耐受.
Objective To evaluate the results of combined chemotherapy with paclitaxel plus nedaplatin in the treatment of advanced endometrial cancer. Result The TP group response rate was 41.2%, The other group was 40.0%. There was no significant difference between the two groups (P > 0.05). Conclusion Paclitaxel combined with nedaplatin in the treatmentof advanced endometrial cancer has good patient compliance, and the toxicities can be tolerated.

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目的观察单药铂类化疗联合放疗治疗宫颈癌的疗效,比较奈达铂或顺铂化疗同步放疗对宫颈癌的近期疗效及不良反应。方法将2006年1月至2011年1月收治的48例宫颈癌患者按随机数字表法分为奈达铂组和顺铂组,每组各24例,两组均采用常规分割放疗及后装治疗,放疗总量8 000~8 500 Gy。奈达铂组患者从放疗第1天起给予奈达铂25 mg/m2静脉滴注,每周1次,共4~5个周期;顺铂组患者放疗第1天起给予顺铂25 mg/m2静脉滴注,每周1次,共4~5个周期。观察两组治疗效果。结果两组患者近期有效率均达100.00%,奈达铂组完全缓解20例(83.33%),顺铂组完全缓释19例(79.17%),两组比较,差异无统计学意义(P0.05);在不良反应方面,奈达铂组患者食欲减退、恶心、呕吐发生情况明显低于顺铂组,差异有统计学意义(P0.05);而白细胞和血小板减少例数,奈达铂组略高于顺铂组,差异无统计学意义(P0.05)。结论单药铂类化疗同步放疗对宫颈癌效果显著,奈达铂或顺铂化疗同步放疗对宫颈癌的疗效相似,但奈达铂致食欲减退、恶心、呕吐反应较顺铂轻,耐受性优于顺铂。
Objective To observe the clinical efficacy of single-agent platinum-based chemotherapy synchronized with radiotherapy for cervical cancer ,and compare the short-term curative effects and adverse reaction between nedaplatin or cisplatin respectively synchronized with radiotherapy for cervical cancer. Methods Totally 48 patients with cervical cancer were divided into nedaplatin group and cisplatin group based on random number table ,24 cases in each group. Both groups adopted conven-tional segmentation radiation treatment and after-loading radiotherapy,to a total dose of 8 000-8 500 Gy. The nedaplatin group was with intravenous drip of nedaplatin 25 mg/m2 from the first day,once a week,totally 4-5 times;the cisplatin group was with intravenous drip of cispaltin 25 mg/m2 from the first day,once a week,totally 4-5 times. The therapeutic effect in the two groups were observed. Results The short-term effective rate in both groups reached 100.00%. Complete remission of nedaplatin group occurr

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建立注射用奈达铂细菌内毒素检查法。方法:按《中国药典》2010年版二部附录XI E进行试验和结果判断。结果:注射用奈达铂对鲎试剂与细菌内毒素的反应不存在干扰。结论:使用细菌内毒素检查法检查注射用奈达铂中的细菌内毒素是可行的,可用细菌内毒素检查法替代家兔热原检查法。
Objective:To establish a detection method for bacterial endotoxins in nedaplatin for injection. Methods:The experi-ment was carried out and the result was evaluated according to the appendix XIE of Chinese Pharmacopoeia 2010 Vol. II. Results:There was no interference from nedaplatin for injection to bacterial endotoxin in TAL reaction. Conclusion:The method is feasible to detect bacterial endotoxin in nedaplatin for injection, which can replace the rabbit pyrogen test.

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【目的】观察比较奈达铂联合多西他赛化疗方案与顺铂联合多西他赛化疗方案治疗晚期非小细胞肺癌（NSCLC ）的近期疗效及不良反应。【方法】本院70例晚期NSCLC患者根据使用化疗药物不同分为两组，分别为奈达铂联合多西他赛治疗36例，顺铂联合多西他赛治疗34例。具体用药方案为奈达铂组：采用奈达铂25 mg/（m2· d），d1～3给予，多西他赛75 mg/m2，d1。顺铂组：采用顺铂25 mg/（m2· d），d1～3给予，21 d为1个周期，化疗2个周期后按WHO标准评价疗效及不良反应。【结果】奈达铂组：完全缓解（CR）1例，部分缓解（PR）14例，稳定（SD）18例，进展（PD）3例，有效率（RR）为41．7％（15/36）；顺铂组：CR 1例，PR 13例，SD 18例，PD 2例，有效率（RR）41．2％（14/34），两组有效率比较差异无显著性（ P ＞0．05）。消化道反应：奈达铂组和顺铂组分别为5．6％（2/36）和29．4％（10/34），两组相比较差异有显著性（ P ＜0．01）；肾毒性分别为0（0/36）和5．9％（2/34）（ P ＜0．05）；骨髓抑制：白细胞减少奈达铂组为72．2％（26/36），顺铂组为70．6％（24/34），两组相比较差异无显著性（ P＞0．05）。【结论】奈达铂联合多西他赛方案治疗晚期NSCLC的有效率不低于顺
Objective To observe and compare the short-term efficacy and adverse reaction of nedaplatin and docetaxel combination chemotherapy regimen vs .cisplatin and docetaxel combination chemotherapy regimen for the treatment of patients with advanced non-small cell lung cancer(NSCLC) .[Methods] According to chemotherapeutics ,70 patients with NSCLC in our hospital were divided into nedaplatin combined with docetaxel group ( n=36) and cisplatin combined with docetaxel group ( n=34) .Nedaplatin group was given nedaplatin 25 mg/(m2 · d) at d1 ~d3 and docetaxel 75mg/m2 at d1 .Cisplatin group was given cisplatin 25 mg/(m2 · d) at d1 ~d3 .The course was 21 days .After 2 cycles of chemotherapy ,the efficacy and adverse reaction were evaluated by WHO standard .[Results] In nedaplatin group ,1 patient was complete remission(CR) ,and 14 pa-tients were partial remission(PR) ,and 18 patients were stable(SD) ,and 3 patients were progression(PD) ,and the effective rate(RR) was 41 .7% (15/36) .I

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