目的：观察人参败毒散加味治疗腹泻型肠易激综合征（IBS-D）的临床疗效。方法：将160例IBS-D患者随机分为3组，治疗组54例口服人参败毒散加减方，中药对照组53例给予参苓白术散，西药对照组53例口服匹维溴胺治疗。3组均连续治疗6周后观察临床疗效及治疗前后临床症状积分情况。结果：总有效率治疗组为85.2%，中药对照组为84.9%，西药对照组为71.7%，治疗组与中药对照组比较，差异无统计学意义（P＞0.05），治疗组与西药对照组比较，差异有统计学意义（P＜0.05）。症状评分治疗前3组无显著差异（P＞0.05）；3组治疗后与本组治疗前比较，差异有统计学意义（P＜0.05）；治疗后治疗组与中药对照组、西药对照组比较有统计学意义（P＜0.05）。结论：人参败毒散加味治疗IBS-D有良好的临床疗效。

Objective:To explore therapeutic effects of modified RenShen BaiDu powder in treating irritable bowel syndrome of diarrhea (IBS-D) pattern. Methods:Altogether 160 patients were randomized into three groups, 54 cases of the treatment group were given with modified RenShen BaiDu powder, 53 cases of the control group of herbs with ShenLing BaiZhu powder, and 53 cases of the control group of western medicine with pinaverium bro-mide tablets. The scales of clinical symptom before and after treating, clinical effects of three groups were observed when three groups have been treated for six weeks consecutively. Results:Total effective rate of the treatment group was 85.2%, higher than 84.9%of the control group of herbs and 71.7%of the control group of western medicine, there was no statistical meaning when the treatment group was compared with the control group of herbs (P>0.05), it had statistical meaning when the treatment group was compared with the control group of western medicine (P 0.0

分别建立了清瘟败毒散超微粉中黄芩苷的薄层鉴别方法和含量测定方法。采用聚酰胺薄膜为薄层板，乙酸乙酯－甲酸（6∶1）为展开剂，1％三氯化铁乙醇溶液为显色剂，可快速鉴别出黄芩苷成分。高效液相色谱法的色谱条件为：色谱柱为Hypersil ODS2 C18，流动相为甲醇－水－磷酸（47∶53∶0．2），检测波长为280 nm。结果显示，黄芩苷在12～72μg／mL范围内线性关系良好，平均回收率为99．12％。黄芩苷在清瘟败毒散超微粉中的含量相对较高，且稳定可靠，可以作为质量控制的指标。

A TLC identification method and a quantitative determination mthod were established for baicalin in Qingwen Baidu San ultra-fine powder. The polyamide chromatography plate was used, developing solvent was acetidine- formic acid ( 6 ∶ 1 ) and the chromogenic agent was 1% ferric chloride ethanol solution. In this condition, baicalin was identified quckly. The HPLC methods were as follows: chromatographic column was Hypersil ODS2 C18, mobile phase was methanol - water - phosphate ( 47 ∶ 53 ∶ 0. 2 ) , and the detective wavelength was 280 nm. Results showed that baicalin had good linear relationship in the range of 12~72μg/mL, the average recovery rate was 99.12%. The content of baicalin in Qingwen Baidu San ultra-fine powder was high and stable,so it can be used as the quality index.

目的探讨登革热的中医病因病机及辨证治疗规律。方法采用回顾性病例调查研究设计，对2013年收治的257例登革热病例的发病特征、中医证候、治疗方案等情况进行收集、整理与分析。结果病例中有6种常见的证型，包括卫气同病、气分热盛、暑湿中阻（袭表）、气血两燔、邪伏膜原、瘀毒交结，相对应的常见的选方有银翘散、柴葛解肌汤、新加香薷饮、清瘟败毒饮、达原饮、犀角地黄汤等。结论广州地区登革热病例的中医卫气营血辨证多为气分热盛，兼有营血分证，且大多夹湿，治则上宜用寒凉之品以清解气分热毒，兼以凉血透气和祛湿。

Objective To explore the etiology, pathogenesis, syndrome differentiation and treatment for dengue fever according to the theory of traditional Chinese medicine ( TCM) . Methods A retrospective case analysis was carried out in 257 dengue fever patients admitted in 2013 by Guangdong Provincial Hospital of Traditional Chinese Medicine. The clinical data of pathogenic features, TCM symptoms and signs, and therapeutic regimen were collected and analyzed. Results Six commonly-seen TCM syndrome patterns for dengue fever were classified into disease involving both defensive system and Qi system, excessive heat in defensive system, summer-heat and dampness stagnating the middle-jiao or attacking the exterior, excessive heat in both Qi system and blood system, pathogenic factors lodging between diaphragm and pleura, and mixture of blood stasis and toxicity, and the corresponding prescriptions were Yinqiao Powder, Chaige Jieji Decoction, Xinjia Xiangru Decoction, Qingwen Baidu Decoctio

目的 分析新型人感染H7N9禽流行性感冒的临床特点以及结合中药治疗的预后.方法 2013年4月5日至2013年4月19日上海市公共卫生临床中心收治的H7N9禽流行性感冒患者18例.根据病情严重程度分为轻症组8例和重症组10例.在抗病毒、抗感染、激素和人免疫球蛋白治疗的同时,轻症组予以银翘散合升降散加减治疗,重症组予以清瘟败毒饮或宣白承气汤加减治疗.分析两组基线情况,评价预后,并探讨预后相关因素.正态分布资料采用t检验,非正态分布资料采用秩和检验,分类变量采用x2检验和Fisher确切概率法,影响因素采用单因素和多因素Logistic回归分析.结果 基线水平,重症组C反应蛋白为(102.61±30.80) mg/L,明显高于轻症组患者的(38.44±22.31) mg/L(t＝4.717,P＜0.01).重症组CD3+ 、CD4+、CD8+和CD45+T淋巴细胞水平明显降低(均P＜0.05).与含激素和人免疫球蛋白治疗相比,含中药的治疗方案可获得较高的康复率(12/14).单因素Logistic回归分析结果显示,肌红蛋白为影响H7N9禽流行性感冒患者预后的危险因素(P=0.029).多因素Logistic回归分析结果显示,肌红蛋白的升高可能为影响H7N9禽流行性感冒患者预后的危险因素(P=0.053).结论 重症H7N9禽流行性感冒患者炎性活动明显,细胞免疫功能低下.中西医结合治疗人感染H7N9禽流行性感冒患者疗效确切,可一定程度改善患者预后.

Objective This study aimed to analyze the clinical features of novel H7N9 avian influenza virus infection in human and its prognosis after integrative treatment.Methods Eighteen H7N9 infected patients were admitted to Shanghai Public Health Clinical Center from 5 April 2013 to 19 April 2013,and were divided into mild group (8 cases) and severe group (10 cases) based on their baseline disease conditions.Patients in mild group were administered modified Yinqiao powder and Shengjiang powder,while patients in severe group were administered modified Qinwen Baidu Decoction or Xuanbai Chengqi Decoction,in addition to antiviral,anti infection,glucocorticoids and human immunoglobulin treatment in both groups.Baseline characteristics and outcomes of these patients were analyzed,and factors associated with prognosis were also evaluated.Measurement data were compared by t test or rank sum test,categorical variables were compared by chi square test or Fisher exact test.Factors associated with progn

目的：改进和优化清热败毒合剂的制剂提取工艺。方法采用双提法提取金银花等药物，通过高效液相色谱测定清热败毒合剂中绿原酸的含量。运用SPSS软件进行方差分析，通过对指标成分进行综合评分确定最佳提取工艺。结果确定其最佳条件为加水量8倍，浸泡60 min，煎煮时间为2 h，煎煮2次。结论绿原酸含量高于原有的提取工艺，改进的提取工艺优于原有的工艺。

Objective To optimize the extraction process for Qingre Baidu mixture which has the heat-clearing and detoxifying actions. Methods Two extraction methods were used. Firstly,aqueous extraction and steam distillation were used for Flos Lonicerae, and then the content of chlorogenic acid was assayed by HPLC. SPSS software was used for the analysis of variance and the extraction process was optimized after comprehensive analysis of the indicative components. Results The optimized extraction process condition was as follows:soaking the herbs of the decoction with 8 times of water for 60 min, and then decocting for two times, 2 hours for each time. Conclusion Higher chlorogenic acid has been obtained through the improved extraction process, indicating that the improved process is superior to the conventional process.