目的 探究带状疱疹患者使用阿昔洛韦、伐昔洛韦和利巴韦林等三种不同抗病毒药物实际应用中成本-疗效分析,为临床用药提供指导意义.方法 选取自2009年3月到2014年5月来我院就治并确诊为带状疱疹患者126例,采用随机抽样分为三组,其中A组采用阿昔洛韦抗疱疹病毒药物治疗,B组采用伐昔洛韦抗疱疹病毒药物治疗,C组采用利巴韦林广谱抗病毒药物治疗,观察分析三组患者临床有效率和治疗成本状况并计算成本/效果比.结果 治疗结束后,三组(A、B、C)患者治疗成本费分别为594.23±96.75元、721.77±101.32元、518.46±89.16元,相互之间存在显著统计学差异(t =6.003,3.729,9.509,P<0.01).治疗效果方面,A组有效率(84.78%)和B组有效率(92.68%)远远超过C组有效率(71.79%),但A、B两组间不存在差异(x2=1.330,P>0.05).住院时间上,A组患者要高于B组(t=2.254,P<0.05),成本-效果比方面,A组(696.06)小于B组(772.11).结论 衡量治疗成本和疗效,从长远看,阿昔洛韦可以作为治疗首选药物,近期快速控制方面,伐昔洛韦可以作为首选药物.
Objective To analysis the cost and antiviral drug efficacy of herpes zoster patients using acyclovir,valaciclovir and Leigh Bhave Lin,and to provide guidance for clinical treatment.Methods 126 patients diagnosed as herpes zoster were selected by random sampling and were divided into three groups from March 2009 to May 2014 in the hospital,group A using acyclovir resistant herpes simplex virus drug therapy,group B with valacyclovir against herpes simplex virus drug therapy,and group C with Leigh Bhave Lin broad-spectrum antiviral drug treatment.Clinical efficiency and cost of treatment status of the three groups patients were analyzed and the cost/effect ratio was calculate.Results After the treatment,three groups (A,B,C) of patients with treatment costs were respectively 594.23 + 96.75 yuan,721.77 ± 101.32 yuan,518.46 ± 89.16 yuan.There was significant difference between each other (t =6.003,3.729,9.509,P =0.000 <0.01).For the effect of treatment,the effective rate of A gr