目的 HPLC法测定追风搜骨宁丸中马钱子碱和士的宁含量。方法采用HPLC法,以光电二极管阵列检测器（PDAD）,色谱柱CAPCELL PAK MG C18（4.6mm×250mm 5（m）,马钱子碱、士的宁[含量测定]项下流动相为乙腈-0.01mol/l辛烷磺酸钠与0.02mol/l磷酸二氢钾等量的混合溶液（用10%磷酸调节ph值2.8）（23;77）,流速1.0ml/min,检测波长为260nm,柱温30℃,对制剂中马钱子碱、士的宁进行定量测定。结果 HPLC法测定马钱子碱在0.0229~0.172μg范围内均呈良好的线性关系,r=0.9991,加样回收率为96.65%,RSD=0.94%;HPLC法测定士的宁在0.0423~0.317μg范围内均呈良好的线性关系,r=0.9998,加样回收率为97.81%,RSD=2.88%。结论该方法操作简便、专属性、重现性好,可有效地测定追风搜骨宁丸中马钱子碱和士的宁的含量。

Objective To determine the content of brucine and strychnine in Zhuifeng Souguning Pills by HPLC .Methods The content of hydroxyl safflower Brucine and Strychnine was determined by HPLC ,which was conducted with a PDAD detecter and the detection wavelength set at 260nm.The column was CAPCELL PAK MG)C18(4.6mm ×250mm,5(m)with mobile phase consisted of acetonitrile-Octane sulfonate with 0.02mol/l potassium dihydrogen phosphate mixed solution of equal (with 10%phosphoric acid to adjust the ph 2.8)(23∶77)and the flow rate was 1.0ml/min.The column temperature maintained at 30℃.Results HPLC determined that hydroxyl safflower Brucine was in range from 0.0229 to 0.172μg, which presented a good linear relationship ( r=0.9991 ) .The average recovery was 96.65%, RSD was 0.94%.HPLC determined that hydroxyl safflower Strychnine was in range from 0.0423 to 0.317μg, which presented a good linear relationship ( r=0.9998) .The average recovery was 97.81%, RSD was 2.88%.Conclusion The meth

辽代马盂山得名于辽代习见的生活器皿马盂；又有永安山、明安山、马云山等别名。马盂山是分散的个体的，喀喇沁旗、宁城县、平泉县都有自己的马盂山。马盂山又是一个整体，是今日的大兴安岭南麓之七老图山脉。马盂山是土河、三肤河、阴凉河的发源地。喀喇沁旗、宁城县、平泉县同属马盂山覆盖范围的一部分；马盂山（永安山、明安山）在契丹民族的发生、发展过程中占有重要地位。首先是契丹民族的发源地，又是契丹社会上层人物的归宿地，更重要的曾经是契丹时辽朝四时捺钵的重要场所。

Mayu Mountain in Liao Dynasty gets its name from the Mayu is a common life ware in Liao Dy-nasty , also known as Yong''an Mountain、Ming''an Mountain or Mayun Mountain and so on. Mayu Mountain is dispersion of the individual, Harqin Banner、Ningcheng County, Pingquan county have their own mountain. Mayu mountain as a whole, is today''s called Qi Laotu Mountain in the Daxing''an Mountains southern. Mayu Mountain is the places where Tu River, Sanfu River and Yinliang River originated . Harqin Banner、Ningcheng County, Pingquan county belong to the same part of the Mayu Mountain range; Mayu Mountain、Yong''an Mountain、Ming''an Mountain in the process of the occurrence and development of Khitan nationality occupies an important position. First of all, is the birthplace of Khitan nationality, And the home of Khitan social elites, more important was the khitans evolvement are an important part in Nabo.

本文以古文献为依据，辅以实地调查，进一步充实对“形类马盂”的马盂山峰（今宁城、平泉两县交界的大尖山峰）的认定证据；另对古籍中所载狭义、广义的马盂山作诠释。

In this paper, based on ancient literature, supplemented by field survey, further enrich the“mayu class”cognize evidence about MaYu Mountain (now border region of Ningcheng and Pingquan''s Da-jian Mountain ); Another is interpretive about MaYu Mountain limited and broad sense records in the an-cient books.

目的：采用 HPLC法同时测定腰腿痛丸中麻黄碱、士的宁和马钱子碱的含量。方法采用 HPLC法。色谱柱为安捷伦C18色谱柱（250 mm ×4．6 mm ，5μm）；流动相为乙腈-1 mL · L -1磷酸（12∶88）；流速为1．0 mL · min-1；检测波长为210和254 nm ；柱温为30℃。结果麻黄碱在1．0～25μg·mL -1范围内线性关系良好（r＝0．9999），平均回收率为98．7％；士的宁在2．0～50μg·mL -1范围内线性关系良好（r＝0．9998），平均回收率为99．1％；马钱子碱在2～50μg·mL -1范围内线性关系良好（r＝0．9999），平均回收率为97．9％。3批腰腿痛丸中麻黄碱、士的宁及马钱子碱的平均含量分别为93．1，106．7和76．8μg · g -1。结论该方法灵敏，精密度好，结果准确可靠。

Objective To establish an HPLC method for the simultaneous determination of ephedrine ,strychnine and brucine in Yaotuitong Pills .Methods The samples were separated on an Agilent C18 (250 mm × 4 .6 mm ,5μm) at 30 ℃ and detected at 210 and 254 nm .The mobile phase was consisted of acetonitrile-1 mL · L -1 phosphoric acid (12 ∶ 88 ) with a flow rate of 1 .0 mL · min-1 . Results The linear ranges of ephedrine ,strychnine and brucine were 1 .0-25 μg · mL -1 (r=0 .999 9) ,2 .0-50 μg · mL -1 (r=0 .999 8) ,2 .0-50 μg · mL -1 (r=0 .999 9) and the average recoveries were 98 .7% ,99 .1% and 97 .9% .The average contents of ephedrine ,strychnine and brucine in three batches of Yaotuitong Pills were 93 .1 ,106 .7 and 76 .8μg · g -1 .Conclusion The meth-od is sensitive ,accurate ,and can be used to control the quality of Yaotuitong Pills .

目的：了解含马钱子中成药的剂型分布及入药的特点。方法：对2010年版《中国药典》收录的14个含有马钱子的中成药进行统计分析。结果：药典收载的14个含马钱子提取工艺的中成药中，马钱子直接打粉入药的占78.6%，功能主治上以活血化瘀、通经活络、理气止痛为主。结论：马钱子的主要活性成分为士的宁和马钱子碱，2010年版《中国药典》收载的含马钱子的中成药制剂制法与剂型均比较单一，马钱子在制剂中作用比较固定、缺乏变化，可知由于马钱子有大毒，临床上运用马钱子还是受到较大限制，因此应当多方面、多层次加大对马钱子配伍及炮制方法的研究，使马钱子的功效得到最大发挥。

Objective:To investigate formation and medication feature of prepared TCM medicine containing Maqianzi. Methods:14 prepared TCM medicine collected in Chinese pharmacopoeia 2010 edition were statistically analyzed. Results:78.6%of Maqianzi were powdered in 14 prepared TCM medicine, focusing on Huoxue Huayu, Tongjing Huoluo and Liqi Zhitong. Conclusion:Strychnine and brucine are the major active constituents of Maqianzi. Preparation and formation of prepared TCM medicine containing Maqianzi in Chinese pharmacopoeia 2010 edition were single;Maqianzi’s functions were unique and changeless. Clinical application of Maqianzi was confirmed due to strong toxicity. So compatibility and processing methods of Maqianzi should be studied in many ways and different levels for better effects.