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双语推荐：素体阳虚

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研究鹿茸益肾胶囊治疗肾阳虚证阳痿的药效学机制。方法:观察鹿茸益肾胶囊对去势雄性大鼠阴茎勃起潜伏期的影响,对去势雄性大鼠附性器官和垂体、肾上腺、胸腺、脾脏质量系数的影响,对去势雄性大鼠性腺内分泌激素血清含量的影响,对氢化可的松致阳虚模型小鼠的影响。结果:鹿茸益肾胶囊能够提高去势雄性大鼠阴茎对刺激的兴奋性,显著缩短勃起潜伏期,提高去势雄性大鼠附性器官的质量系数;提高去势雄性大鼠垂体、肾上腺质量系数;降低去势雄性大鼠胸腺、脾脏质量系数;显著升高大鼠血清睾酮(T)、皮质醇(F)含量、显著降低血清促黄体生成素(LH)、促卵泡刺激素(FSH)含量;显著改善阳虚小鼠的阳虚症状,增强生命力。结论:鹿茸益肾胶囊具有温阳益肾的作用,可用于治疗肾阳虚证阳痿、性功能减退。.
Objective: To study the pharmacodynamic mechanism of lurongyishen capsules in the treatment of impotence with kidney yang deficiency syndrome. Methods: To observe the effects of lurongyishen capsules on penile erection latency in castrated male rats, the effects on the accessory sex organs, pituitary, adrenal, thymus and spleen weight coefficient of castrated male rats, the influence on their serum gonadal hormone content and the impact on hydrogen hydrocortisone induced yang deficiency model mice. Results: Lurongyishen capsules can improve the excitation of the penis to stimulation of castrated male rats and significantly shorten the erectile latency, improve the accessory sex organs, pituitary and adrenal weight coefficient, reduce the thymus and spleen weight coefficient, significantly increase rats’ serum testosterone(T) and cortisol (F) levels, decrease serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) contents, improve yang deficiency syndrome and enhance the

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目的研究右归丸对肾阳虚大鼠垂体-性腺轴的动态影响。方法选取SD雄性大鼠90只,随机分为正常对照组,模型组和右归丸组。大鼠后肢肌内注射氢化可的松,连续29天,制造肾阳虚证模型。正常对照组、模型组和右归丸组SD雄性大鼠于第8天分别用生理盐水和右归丸煎液灌胃,连续22天。分别于第15、23、30天后采用血清放射免疫法测定SD大鼠血清中垂体-性腺轴激素促卵泡激素(FSH)、黄体生成素(LH)、睾酮(T)的含量,并取垂体和睾丸称取重量。结果右归丸对肾阳虚大鼠垂体-性腺轴的动态变化有明显的调整作用。在实验早期(第15天),FSH与LH、T波动幅度不一致。结论右归丸对肾阳虚大鼠垂体-性腺轴的调整呈动态变化。
Objective To explore the change law of kidney yang deifciency syndrome, the dynamic effects of yougui bolus on pituitary-gonad axis in the kidney yang diifciency rats was observed. Method 90 SD male rats were randomly divided into 3 groups, normal control group, model group and yougui bolus group. The rats were given hydrocortisonc by intramuscular injection for 29 days to made diifciency of kidney yang models. Rats in normal control group and model group were administered with normal saline by oral gavage, and rats in yougui bolus group were given by yougui bolus from the 8th day for 22 days. Hormone contents of FSH (follicle stimulating hormone), LH (luteinizing hormone) and T (testosterone) in sera of the pituitary-target gland axises were measured by radioimmunoassay on the 15th day, 23th day and 30th day. Pituitary and testis were weighed. Result There was an obvious adjustment function of yougui bolus on pituitary-goand axis in rats with kidney yang deficiency. In the early perio

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目的：研究慢性再生障碍性贫血患者的性激素水平与中医证候和中医证型的相关性。方法使用德国SIEMENS公司Centaur XP全自动电化学发光免疫分析系统进行检测分析慢性再生障碍性贫血患者的促卵泡生成素、促黄体生成素、泌乳素、孕酮、雌二醇、睾酮等6项性激素水平。结果①慢性再生障碍性贫血患者的性激素水平均在正常范围；②中医辨证主要症状中的"心悸气短"症状在慢性再生障碍性贫血患者中的排卵期女性最常见，"头晕"症状在绝经期女性最少见；③中医次要症状中的"手足心热"和"尿黄"症状在排卵期女性最常见；④按中医证型分类，男性和黄体期女性以肾阳虚型多见（7/12），排卵期和绝经期女性以肾阴虚型多见；⑤虽然中医辨证肾阳虚在男性多见，但其肾阳虚和肾阴虚组的激素水平在组间无差异。结论①慢性再生障碍性贫血患者的性激素水平未受到雄激素的影响，仍在正常范围；②"心悸气短"和"头晕"等主要症状、"手足心热"等次要症状同时出现似可提示女性慢性再生障碍性贫血患者所处的生理期为排卵期；③女性慢性再生障碍性贫血患者的排卵期和绝经期与中医辨证肾阴虚型明显相关，女性慢性再生障碍性贫血患者的黄体期与中医辨证肾阳虚明显相关，未发现慢性再生障碍性贫血患者性激素水平与中医证型的明显相关性，可能与病例数量较少有关。
Objective:Relations between gonadal hormone conentrations and traditional Chinese syndromes of Chronic aplastic anemia. Methods:Detections were done on fol icle, luteinizing hormone, prolactin, pregnendione, estriol and testosterone in aplastic anemia patients with ful -automatic electrochemluminescence and immunoassay made by SIEMENS Company. Results:Firstly, gonadal hormone concentrations of aplastic anemia patients were in normal levels. Secondly, palpitation and short of breath were seen mainly in female patients during ovulatory period , dizziness rarely in female ones during menopause. Thirdly, warmness of hands and feet and yel ow urine were shown obviously in female cases during ovulatory period. Fourthly, based on syndrome of TCM, kidney-yang deficiency was always in male and female patients during luteal phase (7/12), kidney-yin deficiency was mostly in female patients during ovulatory period and menopause. Final y, though kidney-yang deficiency were obviously in males , horm

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为什么治疗恶性肿瘤寒凉药不可多用,其原因有二,一是恶性肿瘤的发病及发展中、或在手术后、放化疗、介入等方法治疗后,会产生气血津液大量的亏损,甚至逐渐形成阳虚。二是患者素体阳虚或感受寒邪的入侵而造成恶性肿瘤。总结了该病虚寒者多,实热者少,正虚邪实者多,单独邪实者少,所以治疗该病是扶正祛邪者多,单独泻实者少,可以看到,伤气、伤阳的寒凉药即不可多用了。文中分别列有温阳兼解毒法、温阳兼化痰法、温阳兼化瘀法、温阳兼软坚散结法的不同应用,其中列举了四种方法中的最佳常用药物,最后以温阳法治疗胃癌手术后,中阳损伤的实际案例。
There are two reasons to illustrate that drugs in cold nature cannot be used too common in treating malignant tumor:a. In the formation and development of a malignant tumor, postoperation, after radiotherapy, chemotherapy or interventional therapy, Qi, blood and body fluid will be seriously deficient, and the deficiency of Yang will gradually form. b. Patients with Yang deficiency or wind-cold fettering the exterior have tendency to develop malignant tumors. Overall, deficient cold syndrome is more common than excess heat syndrome in malignant tumors, and most patients have deficient syndrome. Therefore, strengthening the body resistance to eliminate pathogenic factors is more common used than reducing excess, drugs in cold nature which will hurt Qi and Yang cannot be used too often. In this paper, the different application of warming yang and detoxification method, warming yang and reducing phlegm method, warming yang and dispersing blood stasis method and warming yang and resolving h

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观察针刺加温针治疗女性阴阳两虚型2型糖尿病(T2DM)的临床疗效。方法:将92例阴阳两虚型T2DM女性患者分为阴虚为主的阴阳两虚型(治疗1组)和阳虚为主的阴阳两虚型(治疗2组),两组各46例。进行针刺加温针治疗3个月。观察两组患者治疗前后空腹血糖(FPG)、空腹瘦素(FLP)、空腹胰岛素(FINS)、胰岛素敏感性指数(ISI)、胰岛素抵抗指数(Homa-IR)、胰岛素分泌指数(Homa-β)及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)水平、体质量、体质指数(BMI)、体脂百分率(F%)。结果:1治疗1组总有效率为69.57%,治疗2组总有效率为84.78%,两组比较差异无统计学意义。2与治疗前相比,两组患者治疗后FLP、FPG、FINS、Homa-IR、TC、TG、LDL-C、体质量、BMI、F%均显著下降(P0.01),ISI、Homa-β、HDL-C显著升高(P0.01)。3治疗后治疗2组FPG、Homa-β和BMI改善优于治疗1组(P0.05)。4治疗后,两组患者的LDC-C、HDC-L达到正常水平,治疗2组的FPG也达到正常水平。结论:1针刺加温针能显著调整阴阳两虚型T2DM患者的脂肪-胰岛轴水平,改善瘦素抵抗和胰岛素抵抗,增强胰岛素敏感性以及胰岛β细胞的功能,纠正患者机体内分泌、糖以及脂质代谢的紊乱。2针刺加温针对阳虚
This study was aimed to observe the clinical effect of acupuncture together with warm acupuncture on fe-male type 2 diabetes mellitus (T2DM) patients of dual deficiency of yin and yang syndrome. A total of 92 female T2DM patients of dual deficiency of yin and yang syndrome were divided into two groups, which were priority of yin deficiency in the type of dual deficiency of yin and yang (group 1) and priority of yang deficiency in the type of dual deficiency of yin and yang (group 2). There were 46 cases in each group. The treatment of acupuncture together with warm acupuncture was given for three month. The observation was made on the fasting plasma glucose (FPG), fasting leptin (FLP), fasting insulin (FINS), insulin sensitivity index (ISI), insulin resistance index (Homa-IR), insulin secre-tion index (Homa-β), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high den-sity lipoprotein cholesterol (HDL-C), body mass, body mass index (BMI

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目的：利用系统生物学技术初步探索糖尿病视网膜病变(DR)阳虚病机的代谢组学基础，以阐释阳虚病机主导DR病情进展的关系。方法：基于前期临床研究结果拟定DR阳虚证候调查表，根据阳虚证的有无，采集89例2型DR患者，并依据中医症状分为无阳虚证组和有阳虚证组，统一收集所有观察对象血浆样本，应用气相色谱-飞行时间质谱(GC-TOFMS)技术进行血浆全代谢组学检测，建立DR分期、阳虚证的血浆代谢组指纹图谱，运用OPLS化学计量学统计方法处理各图谱信息，进行组间代谢组学差异分析，建立相应代谢指纹图谱数据库。结果：代谢组学差异分析显示DR有阳虚证组和无阳虚证组基本分离，较少重叠，临床前期和非增殖期基本重叠，而增殖期和非增殖期基本分离，重叠较少；DR有阳虚证与无阳虚证、增殖期与非增殖期之间在代谢组学方面存在差异。结论：阳虚可能影响机体能量代谢致使机体内环境发生重大变化，诱导引起DR增殖性改变的新生血管因子相关基因表达，使DR从非增殖期转化为增殖期，说明阳虚为DR病情发展的关键病机。
Objective:To explore the metabonomics of Yang deficiency mechanism with systematic biology in order to illustrate the relationship between Yang deficiency and the progression of DR. Method: Yang deficiency syndromes questionnaires of DR were designed according to previous clinical study. Eighty-nine patients with diabetic retinopathy type two were divided to the group of Yang deficiency and without Yang deficiency, serum specimens of all the patients were collected and the metabonomics of the serum were detected with GC-TOFMS technology, the phases of DR and plasma metabolism fingerprint of Yang deficiency pattern were established, the information of different fingerprints was processed with OPLS to analyze the difference between groups in metabonomics and establish the corresponding database. Result:The differences of metabonoics outcomes revealed that the groups of Yang deficiency and without Yang deficiency were basically separated with few overlap, previous and non-hyperplasia phas

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目的：探讨消化性溃疡患者中医体质的临床特点。方法采用横断面研究方法，通过调查问卷收集患者的一般情况、判断体质类型，采用描述性分析、χ2检验等统计学方法，分析消化性溃疡患者体质的分布规律及其与Hp感染、饮食等的相关性。结果消化性溃疡患者体质以阳虚质患者最多，占21.5%，阳虚质患者较非阳虚患者感染Hp有显著差异（P<0.05）。在温热饮食方面，阳虚质患者与非阳虚患者存在差异（P<0.01）。结论阳虚质为消化性溃疡的易感体质，且易感染Hp。体质与饮食有一定的相关性。在今后的防治工作中应重点关注阳虚质人群。
Objective To investigate the clinical characteristics of TCM constitution in patients with peptic ulcer. Methods Used the cross-sectional study method, through the questionnaire survey to collect the general situation of patients and determine physical type. Descriptive analysis and χ2 test and other sstatistical methods to analyze the law of patient’s TCM constitution,as well as the relevance of Hp infection, diet etc. Results Patients with constitution of yang asthenia were the most, accounting for 21.5%. There were significant differences in infecting Hp, which between patients of constitution of yang asthenia and others (P<0.05). In the warm food for a significant difference between the two(P<0.01). Conclusion Constitution of yang asthenia is multiple physical in the patients, and it is susceptible to Hp. There is a certain correlation between fitness and diet. In future work should focus on prevention and treatrment of the patients who have constitution of yang astheni

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以中医传统的阴阳辨证为基础,结合现代人因生活习惯等因素多为"阳虚"体质,探讨阳虚与血管性痴呆(VD)的关系。血管性痴呆的病理因素主要责之于痰和瘀,阳虚是痰瘀化生的基础,痰瘀又使阳虚更甚,同时影响病情的发展,为本病的治疗提供了新的思路与方法。
Basing on yin and yang syndrome differentiation of TCM, combing with modern lifestyle due to many factors such as“Yang deficiency”physical, to investigate the relationship between Yang deficiency and vascular dementia (VD). Pathological factors of vascular dementia mainly lies in phlegm and blood stasis, Yang deficiency is the basis for generating phlegm, phlegm also makes a more serious for Yang deficiency, at the same time affects the disease progresses, this theory provides new ideas and methods for treating VD.

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目的：探讨 IgA 肾病病理与中医虚证的关系。方法：多家医院协作的前瞻性研究方法收集数据，对研究对象行肾穿刺活检病理诊断，进行 Hass 分级、牛津分类、Katafuchi 积分和蒋镭评分，同步进行中医虚证辨证分类，分析各病理指数与中医虚证候的关系。结果：HassⅠ~Ⅱ级气虚类和无虚可辨（简称无虚）类相对较多；HassⅢ级气阴两虚类最多；HassⅣ级肝肾阴虚（简称阴虚）类最多；HassⅤ级脾肾阳虚（简称阳虚）类最多。牛津分类中，M1阳虚类最多；S1气阴两虚类最多，其次为阳虚类；E1、T1阳虚类最多，其次为阴虚类；T2阳虚类最多。Katafuchi 总积分阳虚类最高，其后为阴虚类、气阴两虚类；肾小球病变积分包括肾小球增生、球性硬化评分阳虚类高于其他类型，小球节段性病变积分阳虚类和气阴两虚类高于气虚类与无虚类；小管间质病变积分阳虚类高于其他4类、阴虚类高于其余3类；血管病变积分阳虚和阴虚类高于其他3类。蒋镭评分，内皮细胞增生积分阳虚类和阴虚类高于其他3类；破坏血管袢活动性病变积分气阴两虚类高于无虚类。结论：IgA 肾病病理分级、分类及2种病理积分与中医虚证类型具有一定相关性，中医虚证类型一定程度上可以反映 IgA 肾病病理改变程度及预后，对 IgA 肾病
Objective:To explore the association between microscopic pathology of IgA nephropathy and deficiency syn-drome classification in Traditional Chinese Medicine(TCM). Methods:A prospective study was used to collect data in multi clinical centers. Patients who were included in the study were performed percutaneous renal biopsy and diagnosed with TCM syndrome type simultaneously. Based on the the pathological diagnosis of biopsy samples,the Hass,Oxford,Katafuchi and Jiang’s classification methods were used to calculate scores to analyze the relationship of deficiency syndrome classification of TCM and pathological indexes of IgA nephropathy. Results:For the Hass level,the patients with qi deficiency and asymptomatic syndrome mostly belonged to grade 1 to 2,the majority of qi and yin deficiency syndrome belonged to grade 3,the patients of liver and kidney yin deficiency mostly be-longed to grade 4 and the patients of spleen and kidney yang deficiency syndrome mostly belonged to gr

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目的：寻找肺胀阳虚水泛证的关联性因素，探讨肺胀阳虚水泛证的病理机制。方法对符合诊断标准的临床收治肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者分别采用双抗体夹心酶联免疫法检测尿水通道蛋白－2（aquaporin－2，AQP2）、放射免疫法检测血浆精氨酸加压素（argi－nine vasopressin，AVP）、酶联免疫吸附法检测血浆脑钠素（brain natriuretic peptide，BNP）、钠钾三磷酸腺苷酶（ Na+－K+－ATPase）水平，对阳虚水泛证、肺肾气虚证、痰热郁肺证三证之间相同项目指标分别采用秩和检验法比较相互之间的差异性，用相关分析法比较证型内指标之间的相关性。结果肺胀阳虚水泛证与痰热郁肺证的BNP水平有差异性（ P＜0．05），阳虚水泛证、肺肾气虚证、痰热郁肺证患者尿AQP2以及血浆钠钾ATP酶、AVP之间无统计学差异（ P＞0．05），三组钠钾ATP酶与BNP之间有正相关性（ P＜0．05），阳虚水泛证组及肺肾气虚证组的钠钾ATP酶与AVP之间有显著正相关性（P＜0．01）；BNP与AVP之间有显著正相关性（P＜0．01），阳虚水泛证AQP2与AVP之间有显著正相关性（ P＜0．01）。结论 BNP可能是肺胀阳虚水泛证的关键因素之一，需住院的肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者均有阳虚因
Objective Looking for lung distension water diffusion due to deficiency of Yang the correlation factors of the card , explore the pathogenesis of lung distension water diffusion due to deficiency of Yang the card.Methods To conform to the diagnostic standard of clinical treated lung distension water diffusion due to deficiency of Yang syndrome , lung and kidney deficiency syndrome , phlegm yu lung heat syndrome patients , respectively , with double antibody sandwich enzyme-linked immunoassay detection of u-rine aquaporin-2 ( AQP2 ) , ria method to detect the plasma arginine vasopressin ( AVP ) , enzyme-linked immunosorbent method to detect the plasma Brain natriuretic peptide (BNP), potassium sodium atpase en-zyme levels.To water diffusion due to deficiency of Yang syndrome , lung and kidney deficiency syndrome , phlegm heat yu lung between the three certificates same project indicators Rank and inspection were used respectively to compare the differences between each other .

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