Obstructive sleep apnea syndrome(OSAS) refers toa commonbreathing and sleep disorderduring sleep characterized by consequent decreases in oxygen saturation and arousals from sleep, withrepetitive episodes of either complete (apnea) or partial (hypopnea) obstruction of the upper airway caused by structural abnormality of upper airway ornervous system disease, and is closely correlated tonervous system diseases. This article summarized the associations of OSAS with manynervous system diseases, including stroke,idiopathic intracranial hypertension, seizure, cognitive disorder, vestibular system dysfunction, cerebral venous thrombosis, autonomic nerve dysfunction, depression-anxiety, pain and cerebral white matter diseases, so asto arousethe clinical neurologists to concern andpayattention toOSAS.