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双语推荐：A4*1

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以脱氢松香酸甲酯为原料,通过对其苯环进行硝化、还原、重氮化及偶合等反应合成得到8个新的松香基偶氮化合物,分别为:(1R,4aS)-6-((E)-(4-(二甲基氨基)苯基)偶氮基)-7-异丙基-1,4a-二甲基-8-硝基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(2a)、(1R,4aS)-6-((E)-(5-氰基-2-羟基-1,4-二甲基-6-氧基-1,6-二氢吡啶-3-基)偶氮基)-7-异丙基-1,4a-二甲基-8-硝基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(2b)、(1R,4aS)-6-((E)-(5-氰基-1-乙基-2-羟基-4-甲基-6-氧基-1,6-二氢吡啶-3-基)偶氮基)-7-异丙基-1,4a-二甲基-8-硝基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(2c)、(1R,4aS)-7-((E)-(4-(二甲基氨基)苯基)偶氮基)-1,4a-二甲基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(3a)、(1R,4aS)-7-((E)-(2-羟基萘-1-基)偶氮基)-1,4a-二甲基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(3b)、(1R,4aS)-7-((E)-(4-(二甲基氨基)苯基)偶氮基)-1,4a-二甲基-9-氧基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(5a)、(1R,4aS)-7-((E)-(2-羟基萘-1-基)偶氮基)-1,4a-二甲基-9-氧基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(5b)和(1R,4aS)-6-溴-7-((E)-(2-羟基萘-1-基)偶氮基)-1,4a-二甲基-9-氧基-1,2,3,4,4a,9,10,10a-八氢菲-1-甲酸甲酯(5c),产率分别为57%、33%、30%、36%、39%、39%、40%和38%。产物结构经NMR、IR和元素分析进行表征。紫外测定结果显示在三氯甲烷溶液中它们的最大吸收波长分别为420、454、457、541、493、549、482和550 nm,与脱氢松香酸甲酯相比最大吸收波长分别红移了200、234、237、321、273、329、262和330 nm。
Starting from methyl dehydroabietate, eight rosin-derived azo compounds were synthesized by nitration, reduction, diazonization and coupling reaction. The structures of eight azo compounds (1R,4aS)-methyl 6-((E)-(4-(dimethylamino) phenyl)diazenyl)-7-isopropyl-1,4a-di-methyl-8-nitro-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate (2a), (1R, 4aS)-methyl-6-((E)-(5-cyano-2-hydroxy-1,4-dimethyl-6-oxo-1,6-dihydropyridin-3-yl) diazenyl)-7-isopropyl-1,4a-dimethyl-8-nitro-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate (2b), (1R,4aS)-meth-yl-((E)-(5-cyano-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl) diazenyl)-7-isopropyl-1,4a-dimethyl-8-nitro-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate (2c), (1R,4aS)-methyl-7-((E)-(4-(dimethylamino)phenyl)diazenyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate (3a), (1R,4aS)-methyl-7-((E)-(2-hydroxynaphthalen-1-yl)diazenyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate (3b)

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NAC 转录因子在植物应答非生物胁迫中起重要作用。利用生物信息学分析推测花生栽培种转录因子基因AhNAC4(登录号为 HM776131.1)属于抗旱相关转录因子基因,对比栽培品种山花11号 AhNAC4的2条 cDNA序列(ShrNAC4-a和ShrNAC4-b)及其相应的DNA序列(ShNAC4-a和ShNAC4-b)表明,AhNAC4全长为1244 bp,编码区长度为1050 bp,含有2个内含子,分别位于182~279 bp和547~642 bp处,编码蛋白包含349个氨基酸。从抗旱性不同的32个栽培品种分离得到4类AhNAC4,分别命名为AhNAC4-a1、AhNAC4-a2、AhNAC4-b1和AhNAC4-b2,缩写为a1、a2、b1和b2。a1和a2为等位基因,二者在717 bp处存在1个碱基差异,引起第174位氨基酸的改变,b1和b2为等位基因,二者存在14个SNP位点,其中717 bp和924 bp处碱基的差异引起第174位和第244位氨基酸的改变。供试品种中基因型为 a1a1b1b1、a1a1b2b2、a2a2b1b1、a2a2b2b2的品种数分别为10、5、15和2。从19个野生种中分离得到11类 NAC4的 DNA 序列(Aw1NAC4–Aw11NAC4), Aw1NAC4与栽培种 b1、b2的核苷酸序列同源性最高, Aw2NAC4与栽培种a1、a2核苷酸序列同源性最高。推测栽培种a1基因编码蛋白对花生抵御干旱起关键作用, a1和b1基因编码蛋白的功能与野生种更接近。
NAC transcription factors play an important role in response to abiotic stress of plant. In this paper, bioinformatic analysis indicated that transcription factor geneAhNAC4(accession number HM776131.1) can response to drought signal. The comparison of cDNAs (ShrNAC4-a andShrNAC4-b) and genomic DNAs (ShNAC4-a andShNAC4-b) from Shanhua 11 showed thatAhNAC4 has a full length of 1244 bp and an ORF of 1050 bp, containing two introns at 182–279 bp and 547–642 bp, and encoding 349 amino acids. Four kinds ofAhNAC4 genes, named asAhNAC4-a1, AhNAC4-a2, AhNAC4-b1, andAhNAC4-b2(ab-breviations:a1, a2, b1, andb2), were cloned from 32 cultivars with different drought resistances. Among them a1 anda2 were alleles, with only one locus different between the two genes, leading to the difference of corresponding amino acids at site 174;b1 andb2 were alleles, with 14 SNPs, of which two SNPs led to differences of the corresponding amino acids at sites 174 and 244. There were four genotypes ofAh

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利用算子分块矩阵的技巧,研究了两个算子乘积的{1,3,4}逆的广义逆序律,证明了当R（A）、R（B）以及R（AB）都闭时,（AB）{1,3,4}=B{1,3,4}.A{1,3,4}当且仅当R（B）=R（A＊AB）,或者R（A＊）R（B）且B＊（R（B）∩N（A））=B＋（R（B）∩N（A））。
The reverse order law for {1,3,4}-inverse of the product of two operators is investigated by using the technique of block-operator matrix and when R（A）、R（B）、R（AB） are closed.It is proved that（AB）{1,3,4}=B{1,3,4}·A{1,3,4} if and only if R（B）=R（A＊AB）,or R（A＊）R（B） and B＊（R（B）∩N（A））=B＋（R（B）∩N（A））.

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合成并表征了4种羧酸银(I)配合物：[Ag2(L1)2(A1)2]2·H2O（1），[Ag2(L2)2(A2)3]·H2O（2），[Ag(A3)2]2(L3)·10H2O（3）和[Ag2(A4)2](L4)·4H2O（4）（HL1=3-吡啶甲酸；HL2=3，5-二硝基苯甲酸；H2L3=对苯二甲酸；H2L4=4，4’-联苯二甲酸；A1=2-氨基吡啶；A2=2-氨基嘧啶；A3=4-氨基吡啶；A4=1，6-己二胺）。测定了这4种羧酸银(I)配合物抑制脲酶（urease）的效果。实验结果表明4种羧酸银(I)配合物均具有抑制脲酶的生物活性，其中配合物3的抑制活性最强。研究发现它们抑制脲酶的能力随着羧酸银(I)配合物分子聚合程度的增大而减弱。
Four new silver(I) complexes with aromatic carboxylates,[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]· H2O(2),[Ag(A3)2]2(L3)·10H2O(3) and [Ag2(A4)2](L4)·4H2O(4)(HL1=3-pyridinemethanoic acid;HL2=3,5-dinitrobenzoic acid;H2L3=p-phthalic acid;H2L4=4,4’-biphthalic acid;A1=2-aminopyridine;A2=2-aminopyrimidine;A3=4-aminopyridine;A4=1,6-hexyldiamine),have been synthesized and structurally characterized.Inhibition of jack bean urease by these Ag(I) complexes have been investigated.The Ag(I) complexes (1) (4) possess urease inhibitory activities and complex 3 has the best activity to inhibit urease.It was found that the urease inhibition activity of Ag(I) complexes would decrease with their structural polymerization degree increasing.

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真核翻译起始因子4A（eIF4A）蛋白属于DEAD-box RNA解旋酶家族,具有RNA依赖的ATP酶活性和ATP依赖的RNA解旋酶活性。脊椎动物中已经鉴定出三种eIF4A：eIF4A1、eIF4A2和e IF4A3。除参与翻译起始,eIF4A家族成员在胚胎发育等多种生命过程中也发挥着重要的作用。虽然三种eIF4A在序列上高度相似,但它们的作用不尽相同。eIF4A成员作用的独特性和多样化通常由相互作用的结合蛋白来调节。本文将eIF4A家族成员的最新研究进展,特别是e IF4A成员各自独特的作用作一综述。
The eukaryotic initiation factor 4A ( eIF4A) belongs to the DEAD -box protein family with the activities of RNA -dependent ATPase and ATP -dependent RNA helicase .Three eIF4A proteins, eIF4A1, eIF4A2 and eIF4A3, had been identified from vertebrates .Besides helicase function in translation initiation, the members of eIF4A also play essential roles in many life processes including embryo develop-ment.Although there are highly similar in sequences , the three eIF4A show diverse roles.The specific and diverse functions of eIF4A are usually regulated by interacting partner proteins .In this paper, the recent re-search advances of eIF4A were reviewed, especially the diverse roles of eIF4A family members.

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目的：研究肾移植患者中CYP3A4*1G和CYP3A5*3基因多态性对地尔硫?浓度/剂量比的影响。方法以47例肾移植患者为研究对象，用聚合酶链式反应-限制性内切片段长度多态性方法测定肾移植患者药物代谢酶基因型，用高效液相色谱法测定地尔硫?的血药浓度谷值，比较CYP3A4*1G和CYP3A5*3基因多态性对肾移植患者地尔硫?浓度/剂量比的影响。结果 CYP3 A4*1*1型14例（29.79％）、CYP3A4*1*1G型26例（55.32％），CYP3A4*1G*1G型7例（14.89％），G等位基因分布频率为57.45％，A等位基因分布频率为42.55％；CYP3A5*1*1型6例（12.77％）， CYP3A5*1*3型21例（44.68％）， CYP3A5*3*3型20例（42.55％），G等位基因分布频率为64.89％，A等位基因分布频率为35.11％。肾移植患者中CYP3A4*1G基因多态性对地尔硫?浓度/剂量比有显著影响，CYP3A4*1*1型受者比携带CYP3A4*1G等位基因肾移植患者的浓度/剂量比高1.52倍，差异有统计学意义（ P＜0.05）；而CYP3A5*3基因多态性对浓度/剂量比影响较轻微，且差异无统计学意义。结论肾移植患者中CYP3A4*1G基因多态性对地尔硫?浓度/剂量比有显著影响。
Objective To investigate the impact of the CYP3A4*1G and CYP3 A5*3 polymorphisms on the concentration/dose ratios of dilti-azem in kidney transplant patients.Methods Forty -seven cases of kidney transplant recipients were recruited.CYP3A4 and CYP3A5 geno-types were determined by polymerase chain reaction -restriction fragment length polymorphism.Plasma trough concentration of diltiazem was meas-ured by HPLC.The effects of CYP3A4*1G and CYP3A5*3 gene poly-morphisms on the concentration/dose ratios of diltiazem were evaluated and compared.Results There were fourteen cases of CYP3A4*1*1 (29.79%) homozygous genotype , twenty six cases of CYP3A4*1*1G (55.32%) heterozygous genotype , and seven cases of CYP3A4*1G*1G (14.89%) homozygous genotype.Allele frequencies of CYP3A4*1 and *1G were 57.45%and 42.55%, respectively.There were six ca-ses with CYP3A5*1*1 (12.77%), twenty one cases with CYP3A5*1*3(44.68%), and twenty cases with CYP3A5*3*3(42.55%).Allele frequencies of CYP3A5*1 and *3 were 35.

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以联苯胺为原料,通过三组份串联反应一步合成咪唑[1,5-a]吡啶型离子(L),其结构经1H NMR,13C NMR,IR和X-射线单晶衍射表征。利用荧光光谱研究了L在乙腈中对对苯二甲酸( A1)、4,4′-联吡啶( A2)、吡啶(A3)、丙二酸(A4)、1,8-二氨基萘(A5)等分子的识别性能。结果表明,L对对苯二甲酸具有选择识别性能。
Imidazo[1,5-a]pyridinium salts(L), was synthesized with aniline by a facile three-component coupling. The structure was confirmed by 1 H NMR and 13 C NMR,IR,X-ray crystal diffraction analysis. The recongnition properties of L with p-phthalic acid (A1),4,4′-dipyridyl(A2),pyridine(A3),propanedioic acid(A4),1,8-diaminonaphthalene(A5)were investigated in acetonitrile by fluorescence. The results showed that L exhibited selectively recognition properties for p-phthalic acid.

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本文探索并发现了4H-1,2-噁嗪类化合物合成的新方法,在中性环境下,以溴代丙酮酸肟与Zn/Cu(OAc)2体系作用产生亚硝基乙烯类化合物,再进一步与带有给电子基团的乙烯类化合物进行杂DA环加成反应来合成4H-1,2-噁嗪类化合物,突破了4H-1,2-噁嗪类化合物的合成必须使用碱性环境下这一传统限制条件。首次合成了乙基4,4a,5,6,8a-五氢-苯[e]-1,2-噁嗪-3-羧酸酯(4a),并通过了1HNMR,13C-NMR,IR和元素分析等光谱学的结构表证,另外研究发现乙基4,4a,5,6,7,8a-六氢-1,2-噁嗪吡喃-3-羧酸酯(4c)的合成,采用Zn/Cu(OAc)2体系作为缚酸剂收率(60%)高于使用无水Na2CO3的传统方法(收率50%)。
A new approach in neutral medium to synthesize 4H-1,2-oxazine ring was developed. The ethyl 2-nitrosoacrylate was gen-erated by the reaction of ethyl bromopyruvate oxime with Zn/Cu( OAc) 2 system,which could react in situ with cyclohexadienes to produce the bicyclic 1,2-oxazines 3-ethoxycarbonyl-4,4a,5,6,8a-pantahydro-1,2-benzoxazine(4a) and known compounds 4b,4c respectively. The structure of the compound 4a was determined by1 HNMR,13 C-NMR,IR and elemental analysis. The reaction yield of the product 4c could reach 60%when the Zn/Cu(OAc)2 system was used to take the place of the traditional alkali(50%yield only) as dehydrobromination reagent.

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目的：探讨S100A4和 HIF‐1α与卵巢浆液性囊腺癌预后的关系。方法：收集50例卵巢浆液性囊腺癌，28例卵巢浆液性囊腺瘤和15例正常卵巢组织为对照，采用免疫组织化学法检测S100A4和HIF‐1α的表达，并分析与患者预后的关系。结果：S100A4和HIF‐1α在卵巢浆液性囊腺癌组织中高表达，而在卵巢浆液性囊腺瘤组和正常卵巢组中低表达或不表达。S100A4与HIF‐1α表达呈显著正相关性。S100A4与铂化疗耐药无统计学意义（P＞0．05），HIF‐1α与铂化疗耐药有密切关系（P＜0．05）。S100A4和 HIF‐1α同时表达与铂化疗耐药密切相关（P＜0．05）；同时S100A4和HIF‐1α阳性表达患者的生存时间较阴性者明显减少（P＜0．05）。结论：S100A4和HIF‐1α的表达促进卵巢浆液性囊腺癌的发生发展，并且与患者铂化疗耐药和生存时间相关。
Objective:To study the expression of S100A4 and HIF‐1αprotein in Ovarian Serous Cystadenocarcinoma , analyzed the relationship between the two proteins .Methods:Immunohistochemistry method was used to detect S100A4 and HIF‐1αproteins expression and analysis the correlation of proteins expression in Ovarian Serous Cystadenocarcino‐ma .Results:S100A4 and HIF‐1αin Ovarian Serous Cystadenocarcinoma showed a high expression .S100A4 protein ex‐pression in Ovarian Serous carcinoma was positive relation with HIF‐1αprotein expression .The expression of S100A4 and HIF‐1αprotein existed intimate relation with cisplatin‐based chemotherapy resistance (P<0 .05) .They are associ‐ated with overall survival ,longer the overall survival ,lower the expression (P< 0 .05) .Conclusion:Expression of S100A4 and HIF‐1α existed significant positive correlation .High S100A4 and HIF‐1α expression predicts cisplatin‐based chemotherapy resistance and the overall survival in Ovarian Sero

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核受体NR4A1是核受体NR4A家族中的重要一员,可通过对靶细胞基因转录的调节,参与细胞的增殖、凋亡调控,在肿瘤发生、血管重塑以及类固醇合成等重要生命活动过程中发挥重要作用,其功能受到磷酸化、蛋白质相互作用等多种途径的调控。本文就有关NR4A1的生物学功能及其调控机理的研究进展作一综述。
NR4A1 is an important transcription factor that belongs to NR4A family. NR4A1 plays important roles in numerous cellular responses by regulating the transcription of genes from target cells, including the cell proliferation and apoptosis, tumorigenesis, vascular remodeling and steroidogenic. The function of NR4A1 is regulated by phosphorylation and other interactions among proteins. In this paper, the research progress of NR4A1 in biological function and regulation was reviewed.

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